Abstract：
Inflammatory bowel diseases (IBD) are currently recognized to involve chronic intestinal inflammation in genetically susceptible individuals. Patients with IBD mainly develop gastrointestinal inflammation, but it is sometimes accompanied by extraintestinal manifestations such as arthritis, erythema nodosum, episcleritis, pyoderma gangrenosum, uveitis, and primary sclerosing cholangitis. These clinical aspects imply the importance of interorgan networks in IBD. In the gastrointestinal tract, immune cells are influenced by multiple local environmental factors including microbiota, dietary environment, and intercellular networks, which further alter molecular networks in immune cells. Therefore, deciphering networks at interorgan, intercellular, and intracellular levels should help to obtain a comprehensive understanding of IBD. This review focuses on the intestinal immune system, which governs the physiological and pathological functions of the digestive system in harmony with the other organs.
摘要：
炎症性肠病(IBD)目前被认为涉及遗传易感个体的慢性肠道炎症。IBD患者主要发生胃肠道炎症,但有时伴有肠外表现，如关节炎，结节性红斑,上巩膜炎,坏疽性脓皮病,葡萄膜炎,和原发性硬化性胆管炎.这些临床方面暗示了IBD中器官间网络的重要性。在胃肠道，免疫细胞受到多种局部环境因素的影响，包括微生物群，饮食环境，和细胞间网络，这进一步改变了免疫细胞中的分子网络。因此,破译机构间的网络，细胞间，和细胞内水平应有助于获得对IBD的全面了解。本文对肠道免疫系统,它与其他器官协调地控制消化系统的生理和病理功能。
