Abstract：
The aim of this study is to investigate the relationship between the nationwide cell phone subscription rate and the nationwide incidence of brain tumors in South Korea. The nationwide cell phone subscription rate was used as a proxy for the RF-EMR exposure assessment.
The data for cell phone subscriptions per 100 persons from 1985 to 2019 were found in the Statistics, International Telecom Union (ITU). The brain tumor incidence data from 1999 to 2018 provided by the South Korea Central Cancer Registry operated by the National Cancer Center were used.
In South Korea, the subscription rate increased from 0 per 100 persons in 1991 to 57 per 100 persons in 2000. The subscription rate became 97 per 100 persons in 2009 and 135 per 100 persons in 2019. For the correlation coefficient between cell phone subscription rate before 10 years and ASIR per 100,000, a positive correlation coefficient with a statistical significance was reported in 3 benign brain tumors (International Classification of Diseases, ICD-10 code, D32, D33, and D32.0) and in 3 malignant brain tumors (ICD-10 code, C71.0, C71.1, and C71.2). Positive correlation coefficients with a statistical significance in malignant brain tumors ranged from 0.75 (95% CI 0.46-0.90) for C71.0 to 0.85 (95% CI 0.63-0.93) for C71.1.
In consideration of the fact that the main route for RF-EMR exposure has been through the frontotemporal side of the brain (the location of both ears), the positive correlation coefficient with a statistical significance in the frontal lobe (C71.1) and temporal lobe (C71.2) can be understood. Statistically insignificant results from recent cohort and large population international studies and contrasting results from many previous case-control studies could indicate a difficulty in identifying a factor as a determinant of a disease in ecological study design.
The data for cell phone subscriptions per 100 persons from 1985 to 2019 were found in the Statistics, International Telecom Union (ITU). The brain tumor incidence data from 1999 to 2018 provided by the South Korea Central Cancer Registry operated by the National Cancer Center were used.
In South Korea, the subscription rate increased from 0 per 100 persons in 1991 to 57 per 100 persons in 2000. The subscription rate became 97 per 100 persons in 2009 and 135 per 100 persons in 2019. For the correlation coefficient between cell phone subscription rate before 10 years and ASIR per 100,000, a positive correlation coefficient with a statistical significance was reported in 3 benign brain tumors (International Classification of Diseases, ICD-10 code, D32, D33, and D32.0) and in 3 malignant brain tumors (ICD-10 code, C71.0, C71.1, and C71.2). Positive correlation coefficients with a statistical significance in malignant brain tumors ranged from 0.75 (95% CI 0.46-0.90) for C71.0 to 0.85 (95% CI 0.63-0.93) for C71.1.
In consideration of the fact that the main route for RF-EMR exposure has been through the frontotemporal side of the brain (the location of both ears), the positive correlation coefficient with a statistical significance in the frontal lobe (C71.1) and temporal lobe (C71.2) can be understood. Statistically insignificant results from recent cohort and large population international studies and contrasting results from many previous case-control studies could indicate a difficulty in identifying a factor as a determinant of a disease in ecological study design.
摘要：
背景：本研究的目的是调查韩国全国手机订阅率与全国脑肿瘤发病率之间的关系。全国手机订阅率被用作RF-EMR暴露评估的代理。
方法：统计了1985年至2019年每100人的手机订阅数据，国际电信联盟(ITU)。使用国家癌症中心运营的韩国中央癌症登记处提供的1999年至2018年的脑肿瘤发病率数据。
结果：在韩国，认购率从1991年的每100人0人增加到2000年的每100人57人。2009年的订阅率为每100人97人，2019年为每100人135人。对于10年之前的手机订阅率与每100,000的ASIR之间的相关系数，在3个良性脑肿瘤中报告了具有统计学意义的正相关系数（国际疾病分类，ICD-10代码,D32，D33和D32.0）和3种恶性脑肿瘤（ICD-10代码，C71.0、C71.1和C71.2)。恶性脑肿瘤中具有统计学意义的正相关系数为C71.0的0.75（95％CI0.46-0.90）至C71.1的0.85（95％CI0.63-0.93）。
结论：考虑到RF-EMR暴露的主要途径是通过大脑的额颞侧（双耳的位置），可以理解额叶（C71.1）和颞叶（C71.2）中具有统计学意义的正相关系数。最近的队列和大人群国际研究的统计学意义上微不足道的结果以及许多先前病例对照研究的对比结果可能表明，在生态研究设计中，很难确定一个因素是疾病的决定因素。
方法：统计了1985年至2019年每100人的手机订阅数据，国际电信联盟(ITU)。使用国家癌症中心运营的韩国中央癌症登记处提供的1999年至2018年的脑肿瘤发病率数据。
结果：在韩国，认购率从1991年的每100人0人增加到2000年的每100人57人。2009年的订阅率为每100人97人，2019年为每100人135人。对于10年之前的手机订阅率与每100,000的ASIR之间的相关系数，在3个良性脑肿瘤中报告了具有统计学意义的正相关系数（国际疾病分类，ICD-10代码,D32，D33和D32.0）和3种恶性脑肿瘤（ICD-10代码，C71.0、C71.1和C71.2)。恶性脑肿瘤中具有统计学意义的正相关系数为C71.0的0.75（95％CI0.46-0.90）至C71.1的0.85（95％CI0.63-0.93）。
结论：考虑到RF-EMR暴露的主要途径是通过大脑的额颞侧（双耳的位置），可以理解额叶（C71.1）和颞叶（C71.2）中具有统计学意义的正相关系数。最近的队列和大人群国际研究的统计学意义上微不足道的结果以及许多先前病例对照研究的对比结果可能表明，在生态研究设计中，很难确定一个因素是疾病的决定因素。
