Abstract：
Transcatheter arterial embolization, a minimally invasive treatment to deliberately occlude the blood vessels, has become a safe and effective procedure for the management of vascular diseases and benign/malignant tumors. Particularly, hydrogel-based embolic agents have garnered much attention because of their potential to address some of the limitations of clinically used embolic agents and can be rationally designed to impart more favorable characteristics or functions. In this review, the recent progress toward the development of polymer-based hydrogels for effective endovascular embolization, including the in situ gelling hydrogels mediated by physically or chemically crosslinking, imageable hydrogels for intraprocedural and postprocedural feedback, use of hydrogels as the drug depot for local delivery of therapeutic drugs, hemostatic hydrogels inducing extrinsic or intrinsic coagulation of blood, stimuli-responsive shape memory hydrogels as the smart embolization devices, and hydrogels incorporating external-stimuli functional materials for multidisciplinary therapy, is systemically summarized. Moreover, the potential considerations of hydrogel-based embolic agents confronted in therapeutic embolization are pointed out. Finally, the perspectives for the development of more effective embolic hydrogels are also highlighted.
摘要：
经导管动脉栓塞(TAE),一种故意闭塞血管的微创治疗方法，已成为治疗血管疾病和良性/恶性肿瘤的安全有效的方法。特别是,基于水凝胶的栓塞剂由于其解决临床使用的栓塞剂的一些限制的潜力而引起了很多关注,并且可以合理地设计以赋予更有利的特性或功能。在这次审查中,我们系统地总结了聚合物基水凝胶用于有效血管内栓塞的最新进展，包括通过物理或化学交联介导的原位胶凝水凝胶，用于过程中和过程后反馈的可成像水凝胶，使用水凝胶作为局部递送治疗药物的药物仓库，诱导血液外在或内在凝固的止血水凝胶，刺激响应型形状记忆水凝胶作为智能栓塞装置，和包含外部刺激功能材料的水凝胶，用于多学科治疗。此外，指出了治疗性栓塞中存在的基于水凝胶的栓塞剂的潜在考虑因素.最后,还强调了开发更有效的栓塞水凝胶的前景。本文受版权保护。保留所有权利。
