Abstract：
Nowadays, magnetoelectric nanomaterials are on their way to finding wide applications in biomedicine for various cancer and neurological disease treatment, which is mainly restricted by their relatively high toxicity and complex synthesis. This study for the first time reports novel magnetoelectric nanocomposites of CoxFe3-xO4-BaTiO3 series with tuned magnetic phase structures, which were synthesized via a two-step chemical approach in polyol media. The magnetic CoxFe3-xO4 phases with x = 0.0, 0.5, and 1.0 were obtained by thermal decomposition in triethylene glycol media. The magnetoelectric nanocomposites were synthesized by the decomposition of barium titanate precursors in the presence of a magnetic phase under solvothermal conditions and subsequent annealing at 700 °C. X-ray diffraction revealed the presence of both spinel and perovskite phases after annealing with average crystallite sizes in the range of 9.0-14.5 nm. Transmission electron microscopy data showed two-phase composite nanostructures consisting of ferrites and barium titanate. The presence of interfacial connections between magnetic and ferroelectric phases was confirmed by high-resolution transmission electron microscopy. Magnetization data showed expected ferrimagnetic behavior and σs decrease after the nanocomposite formation. Magnetoelectric coefficient measurements after the annealing showed non-linear change with a maximum of 89 mV/cm*Oe with x = 0.5, 74 mV/cm*Oe with x = 0, and a minimum of 50 mV/cm*Oe with x = 0.0 core composition, that corresponds with the coercive force of the nanocomposites: 240 Oe, 89 Oe and 36 Oe, respectively. The obtained nanocomposites show low toxicity in the whole studied concentration range of 25-400 μg/mL on CT-26 cancer cells. The synthesized nanocomposites show low cytotoxicity and high magnetoelectric effects, therefore they can find wide applications in biomedicine.
摘要：
如今,磁电纳米材料正在寻求在生物医学中广泛应用于各种癌症和神经系统疾病的治疗，这主要受到其相对较高的毒性和复杂的合成的限制。这项研究首次报道了具有调谐磁相结构的CoxFe3-xO4-BaTiO3系列新型磁电纳米复合材料，在多元醇介质中通过两步化学方法合成。通过在三甘醇介质中热分解获得x=0.0、0.5和1.0的CoxFe3-xO4磁性相。磁电纳米复合材料是通过在溶剂热条件下在磁性相的存在下分解钛酸钡前体并随后在700°C下退火而合成的。X射线衍射显示，退火后存在尖晶石和钙钛矿相，平均晶粒尺寸在9.0-14.5nm范围内。透射电子显微镜数据显示了由铁氧体和钛酸钡组成的两相复合纳米结构。通过高分辨率透射电子显微镜证实了磁相和铁电相之间存在界面连接。磁化数据显示，纳米复合材料形成后，预期的亚铁磁行为和σ降低。退火后的磁电系数测量显示出非线性变化，x=0.5时最大为89mV/cm*Oe，x=0时最大为74mV/cm*Oe，x=0时最小为50mV/cm*Oe=0.0核心成分，与纳米复合材料的矫顽力相对应：240Oe，89Oe和36Oe，分别。获得的纳米复合材料在CT-26癌细胞上在25-400μg/mL的整个研究浓度范围内显示低毒性。合成的纳米复合材料显示出低细胞毒性和高磁电效应，因此它们可以在生物医学中找到广泛的应用。
