Abstract：
Ossification of the posterior longitudinal ligament (OPLL) is a heterotopic ossification that may cause spinal cord compression. With the recent development of computed tomography (CT) imaging, it is known that patients with OPLL often have complications related to ossification of other spinal ligaments, and OPLL is now considered part of ossification of the spinal ligaments (OSL). OSL is known to be a multifactorial disease with associated genetic and environmental factors, but its pathophysiology has not been clearly elucidated. To elucidate the pathophysiology of OSL and develop novel therapeutic strategies, clinically relevant and validated animal models are needed. In this review, we focus on animal models that have been reported to date and discuss their pathophysiology and clinical relevance. The purpose of this review is to summarize the usefulness and problems of existing animal models and to help further the development of basic research on OSL.
摘要：
后纵韧带骨化（OPLL）是一种异位骨化，可能导致脊髓压迫。随着近年来计算机断层扫描(CT)成像技术的发展,众所周知，OPLL患者通常有与其他脊髓韧带骨化相关的并发症，OPLL现在被认为是脊髓韧带骨化（OSL）的一部分。已知OSL是一种多因素疾病，具有相关的遗传和环境因素，但其病理生理学尚未明确阐明。阐明OSL的病理生理学并开发新的治疗策略，临床相关和验证的动物模型是必要的.在这次审查中,我们关注迄今报道的动物模型,并讨论其病理生理学和临床相关性.这篇综述的目的是总结现有动物模型的有用性和问题，并帮助进一步发展OSL的基础研究。
