PDF(Pubmed)
Abstract：
Serotonin acts solely via 5-HT4-receptors to control human cardiac contractile function. The effects of serotonin via 5-HT4-receptors lead to positive inotropic and chronotropic effects, as well as arrhythmias, in the human heart. In addition, 5-HT4-receptors may play a role in sepsis, ischaemia, and reperfusion. These presumptive effects of 5-HT4-receptors are the focus of the present review. We also discuss the formation and inactivation of serotonin in the body, namely, in the heart. We identify cardiovascular diseases where serotonin might play a causative or additional role. We address the mechanisms which 5-HT4-receptors can use for cardiac signal transduction and their possible roles in cardiac diseases. We define areas where further research in this regard should be directed in the future, and identify animal models that might be generated to this end. Finally, we discuss in what regard 5-HT4-receptor agonists or antagonists might be useful drugs that could enter clinical practice. Serotonin has been the target of many studies for decades; thus, we found it timely to summarise our current knowledge here.
摘要：
血清素仅通过5-HT4受体起作用以控制人心脏收缩功能。5-羟色胺通过5-HT4受体的作用导致正性肌力和变时作用，以及心律失常，在人类的心脏。此外,5-HT4受体可能在脓毒症中起作用，缺血,和再灌注。5-HT4受体的这些假定作用是本综述的重点。我们还讨论了体内5-羟色胺的形成和失活，即,在心里。我们确定了5-羟色胺可能起致病或额外作用的心血管疾病。我们探讨了5-HT4受体可用于心脏信号转导的机制及其在心脏病中的可能作用。我们确定了今后应该进行这方面进一步研究的领域，并确定为此可能产生的动物模型。最后,我们在哪些方面讨论了5-HT4受体激动剂或拮抗剂可能是可以进入临床实践的有用药物.几十年来，血清素一直是许多研究的目标；因此，我们发现在这里总结我们目前的知识是及时的。
