Abstract：
Remote ischemic preconditioning (RIPC) has been shown to minimize subsequent ischemia-reperfusion injury (IRI), whereas obesity has been suggested to attenuate the efficacy of RIPC in animal models. The primary objective of this study was to investigate the effect of a single bout of RIPC on the vascular and autonomic response after IRI in young obese men. A total of 16 healthy young men (8 obese and 8 normal weight) underwent two experimental trials: RIPC (three cycles of 5 min ischemia at 180 mmHg + 5 min reperfusion on the left thigh) and SHAM (the same RIPC cycles at resting diastolic pressure) following IRI (20 min ischemia at 180 mmHg + 20 min reperfusion on the right thigh). Heart rate variability (HRV), blood pressure (SBP/DBP), and cutaneous blood flow (CBF) were measured between baseline, post-RIPC/SHAM, and post-IRI. The results showed that RIPC significantly improved the LF/HF ratio (p = 0.027), SBP (p = 0.047), MAP (p = 0.049), CBF (p = 0.001), cutaneous vascular conductance (p = 0.003), vascular resistance (p = 0.001), and sympathetic reactivity (SBP: p = 0.039; MAP: p = 0.084) after IRI. However, obesity neither exaggerated the degree of IRI nor attenuated the conditioning effects on the measured outcomes. In conclusion, a single bout of RIPC is an effective means of suppressing subsequent IRI and obesity, at least in Asian young adult men, does not significantly attenuate the efficacy of RIPC.
摘要：
远程缺血预处理（RIPC）已被证明可以最大程度地减少随后的缺血再灌注损伤（IRI）。而肥胖已被认为减弱动物模型中RIPC的功效。这项研究的主要目的是研究一次RIPC对年轻肥胖男性IRI后血管和自主神经反应的影响。共有16名健康年轻男性（8名肥胖和8名正常体重）进行了两项实验：RIPC（在180mmHg下缺血5分钟的三个周期+左大腿再灌注5分钟）和SHAM（在静息舒张压下相同的RIPC周期）IRI（在180mmHg下缺血20分钟+右大腿再灌注20分钟）。心率变异性(HRV),血压（SBP/DBP），和皮肤血流量（CBF）测量之间的基线，后RIPC/SHAM，和IRI后。结果表明，RIPC显著提高了LF/HF比（p=0.027），SBP（p=0.047），MAP（p=0.049），CBF（p=0.001），皮肤血管电导（p=0.003），血管阻力（p=0.001），IRI后交感神经反应性（SBP：p=0.039；MAP：p=0.084）。然而,肥胖既没有夸大IRI的程度,也没有减弱对测量结果的调节效应.总之,一次RIPC是抑制随后的IRI和肥胖的有效手段，至少在亚洲年轻成年男子中，不会显着减弱RIPC的功效。
