Abstract:
Remote ischemic preconditioning (RIPC) has been shown to minimize subsequent ischemia-reperfusion injury (IRI), whereas obesity has been suggested to attenuate the efficacy of RIPC in animal models. The primary objective of this study was to investigate the effect of a single bout of RIPC on the vascular and autonomic response after IRI in young obese men. A total of 16 healthy young men (8 obese and 8 normal weight) underwent two experimental trials: RIPC (three cycles of 5 min ischemia at 180 mmHg + 5 min reperfusion on the left thigh) and SHAM (the same RIPC cycles at resting diastolic pressure) following IRI (20 min ischemia at 180 mmHg + 20 min reperfusion on the right thigh). Heart rate variability (HRV), blood pressure (SBP/DBP), and cutaneous blood flow (CBF) were measured between baseline, post-RIPC/SHAM, and post-IRI. The results showed that RIPC significantly improved the LF/HF ratio (p = 0.027), SBP (p = 0.047), MAP (p = 0.049), CBF (p = 0.001), cutaneous vascular conductance (p = 0.003), vascular resistance (p = 0.001), and sympathetic reactivity (SBP: p = 0.039; MAP: p = 0.084) after IRI. However, obesity neither exaggerated the degree of IRI nor attenuated the conditioning effects on the measured outcomes. In conclusion, a single bout of RIPC is an effective means of suppressing subsequent IRI and obesity, at least in Asian young adult men, does not significantly attenuate the efficacy of RIPC.
摘要:
远程缺血预处理(RIPC)已被证明可以最大程度地减少随后的缺血再灌注损伤(IRI)。而肥胖已被认为减弱动物模型中RIPC的功效。这项研究的主要目的是研究一次RIPC对年轻肥胖男性IRI后血管和自主神经反应的影响。共有16名健康年轻男性(8名肥胖和8名正常体重)进行了两项实验:RIPC(在180mmHg下缺血5分钟的三个周期+左大腿再灌注5分钟)和SHAM(在静息舒张压下相同的RIPC周期)IRI(在180mmHg下缺血20分钟+右大腿再灌注20分钟)。心率变异性(HRV),血压(SBP/DBP),和皮肤血流量(CBF)测量之间的基线,后RIPC/SHAM,和IRI后。结果表明,RIPC显著提高了LF/HF比(p=0.027),SBP(p=0.047),MAP(p=0.049),CBF(p=0.001),皮肤血管电导(p=0.003),血管阻力(p=0.001),IRI后交感神经反应性(SBP:p=0.039;MAP:p=0.084)。然而,肥胖既没有夸大IRI的程度,也没有减弱对测量结果的调节效应.总之,一次RIPC是抑制随后的IRI和肥胖的有效手段,至少在亚洲年轻成年男子中,不会显着减弱RIPC的功效。