PDF(Pubmed)
Abstract：
Mycoplasma genitalium is a newly emerged sexually transmitted disease pathogen and an independent risk factor for female cervicitis and pelvic inflammatory disease. The clinical symptoms caused by M. genitalium infection are mild and easily ignored. If left untreated, M. genitalium can grow along the reproductive tract and cause salpingitis, leading to infertility and ectopic pregnancy. Additionally, M. genitalium infection in late pregnancy can increase the incidence of preterm birth. M. genitalium infections are often accompanied by co-infection with other sexually transmitted pathogens (Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis) and viral infections (Human Papilloma Virus and Human Immunodeficiency Virus). A recent study suggested that M. genitalium plays a role in tumor development in the female reproductive system. However, few studies endorsed this finding. In recent years, M. genitalium has evolved into a new \"superbug\" due to the emergence of macrolide-and fluoroquinolone-resistant strains leading to frequent therapy failures. This review summarizes the pathogenic characteristics of M. genitalium and the female reproductive diseases caused by M. genitalium (cervicitis, pelvic inflammatory disease, ectopic pregnancy, infertility, premature birth, co-infection, reproductive tumors, etc.), as well as its potential relationship with reproductive tumors and clinical treatment.
摘要：
生殖支原体是一种新出现的性传播疾病病原体，是女性宫颈炎和盆腔炎的独立危险因素。生殖支原体感染引起的临床症状较轻，容易被忽视。如果不及时治疗，生殖支原体可以沿着生殖道生长并引起输卵管炎，导致不孕和异位妊娠。此外,妊娠晚期生殖支原体感染可增加早产的发生率。生殖支原体感染通常伴有与其他性传播病原体（沙眼衣原体，淋病奈瑟菌,和阴道毛滴虫）和病毒感染（人乳头瘤病毒和人类免疫缺陷病毒）。最近的一项研究表明，生殖分枝杆菌在女性生殖系统的肿瘤发展中起作用。然而,很少有研究支持这一发现。近年来,由于出现了大环内酯和氟喹诺酮耐药菌株，导致频繁的治疗失败，生殖支原体已演变成一种新的“超级细菌”。本文综述了生殖支原体的致病特征和由生殖支原体引起的女性生殖疾病（cervicitis,盆腔炎,异位妊娠,不孕症,早产,合并感染,生殖肿瘤,等。),及其与生殖肿瘤的潜在关系和临床治疗。
