关键词: Cardiac malignancy Case report Endomyocardial biopsy Heart failure Myeloid sarcoma

来  源:   DOI:10.1093/ehjcr/ytad088   PDF(Pubmed)

Abstract:
UNASSIGNED: Myeloid sarcoma, also known as chloroma, is a pathologic diagnosis for an extramedullary proliferation of blasts of one or more of the myeloid lineages. It is an uncommon manifestation of acute myeloid leukaemia (AML), although the diagnosis may occur prior to or after diagnosis of AML. Cardiac infiltration by myeloid sarcoma is extremely rare, and of the few published cases, a diagnosis of leukaemia was almost always already present.
UNASSIGNED: This is a 52-year-old patient admitted to the hospital with acute shortness of breath, with a large amorphous mass found on computed tomography scan invading the myocardium and causing heart failure. Echocardiography demonstrated multiple cardiac masses. A bone marrow biopsy was non-diagnostic. An endomyocardial biopsy confirmed a cardiac primary myeloid sarcoma. The patient was successfully treated with chemotherapy with complete resolution of the cardiac infiltration and of the heart failure.
UNASSIGNED: We present this rare case of primary cardiac myeloid sarcoma and discuss current literature relevant to this effectively unique presentation. We discuss the use of endomyocardial biopsy in the diagnosis of cardiac malignancy and the advantages of early diagnosis and management of this unusual cause of heart failure.
摘要:
未经批准:髓系肉瘤,也被称为叶绿素,是一种或多种髓系母细胞髓外增殖的病理诊断。这是急性髓性白血病(AML)的罕见表现,尽管诊断可能发生在AML诊断之前或之后。骨髓肉瘤的心脏浸润极为罕见,在少数公开的案例中,白血病的诊断几乎已经存在.
未经证实:这是一名52岁的患者,因急性呼吸急促入院,在计算机断层扫描扫描中发现大量无定形物质侵入心肌并导致心力衰竭。超声心动图显示多个心脏肿块。骨髓活检是非诊断性的。心内膜活检证实为心脏原发性髓样肉瘤。患者通过化疗成功治疗,心脏浸润和心力衰竭完全缓解。
UNASSIGNED:我们介绍了这种罕见的原发性心脏髓样肉瘤病例,并讨论了与这种有效独特表现相关的现有文献。我们讨论了心内膜活检在心脏恶性肿瘤诊断中的应用,以及早期诊断和治疗这种异常心力衰竭原因的优势。
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