PDF(Pubmed)
Abstract：
UNASSIGNED: Fimbristylis miliacea (L.) Vahl (Cyperaceae) is a grass like herb habitually breeds as weed in paddy fields and mostly disseminated in tropical or sub-tropical countries of south and south-east Asia, northern Australia, and west Africa. The plant has been traditionally used to treat fever as a form of poultice. However, no scientific study regarding its toxicity profile has been testified.
UNASSIGNED: The study has been carried out to determine the potential toxicity of the methanol extract from leaves of the Fimbristylis miliacea, employing the technique of acute and subchronic oral administration in mice.
UNASSIGNED: In the acute toxicity study according to OECD guideline 425, oral administration of FM methanol extract at single doses of 2000 and 5000 mg/kg in both sexes of Swiss albino mice was performed. Toxic symptoms, abnormal behavior, changes in body weight, and mortality were observed for 14 consecutive days. In subchronic toxicity study according to OECD guideline 407, plant extract was administered orally at doses of 100, 500, 1000, and 2000 mg/kg daily for 28 days. The general toxic symptoms, abnormal behavior, changes in body weight were observed daily. Biochemical analysis of serum, and histopathological examination of liver were performed at the end of the study.
UNASSIGNED: No mortality, abnormal behavior and urination, changes in sleep, food intake, adverse effect, and non-linearity in body weight have been recorded during acute toxicity study at the doses of 2000 and 5000 mg/kg. Also, in subchronic toxicity study, FM extract produced no mortality or any kind of adverse effects in regards of general behavior, body weight, urination, sleeping routine, and food intake. In case of analysis of thirteen different biochemical parameters, concentrations of aspartate transaminase (AST) and glucose were altered significantly in male and female mice in both acute and subchronic study. Total cholesterol and triglycerides at 5000 mg/kg.bw were changed in male mice in acute toxicity study. On the other hand, female mice had altered triglycerides in subchronic test. All other critical parameters were found unaffected. In subchronic test, histopathological examination of liver demonstrated cellular necrosis at 2000 mg/kg.bw in both male and female mice while minor necrosis was observed at 1000 mg/kg.bw. Thus, the no observed adverse effect level (NOAEL) can be assumed around 1000 mg/kg.bw.
UNASSIGNED: The present study suggests that treatment with FM extract does not reveal significant toxicity.
UNASSIGNED: The study has been carried out to determine the potential toxicity of the methanol extract from leaves of the Fimbristylis miliacea, employing the technique of acute and subchronic oral administration in mice.
UNASSIGNED: In the acute toxicity study according to OECD guideline 425, oral administration of FM methanol extract at single doses of 2000 and 5000 mg/kg in both sexes of Swiss albino mice was performed. Toxic symptoms, abnormal behavior, changes in body weight, and mortality were observed for 14 consecutive days. In subchronic toxicity study according to OECD guideline 407, plant extract was administered orally at doses of 100, 500, 1000, and 2000 mg/kg daily for 28 days. The general toxic symptoms, abnormal behavior, changes in body weight were observed daily. Biochemical analysis of serum, and histopathological examination of liver were performed at the end of the study.
UNASSIGNED: No mortality, abnormal behavior and urination, changes in sleep, food intake, adverse effect, and non-linearity in body weight have been recorded during acute toxicity study at the doses of 2000 and 5000 mg/kg. Also, in subchronic toxicity study, FM extract produced no mortality or any kind of adverse effects in regards of general behavior, body weight, urination, sleeping routine, and food intake. In case of analysis of thirteen different biochemical parameters, concentrations of aspartate transaminase (AST) and glucose were altered significantly in male and female mice in both acute and subchronic study. Total cholesterol and triglycerides at 5000 mg/kg.bw were changed in male mice in acute toxicity study. On the other hand, female mice had altered triglycerides in subchronic test. All other critical parameters were found unaffected. In subchronic test, histopathological examination of liver demonstrated cellular necrosis at 2000 mg/kg.bw in both male and female mice while minor necrosis was observed at 1000 mg/kg.bw. Thus, the no observed adverse effect level (NOAEL) can be assumed around 1000 mg/kg.bw.
UNASSIGNED: The present study suggests that treatment with FM extract does not reveal significant toxicity.
摘要：
未经批准：鱼腥草（L.）Vahl（莎草科）是一种草类草本植物，习惯性地在稻田中作为杂草繁殖，主要散布在南亚和东南亚的热带或亚热带国家，澳大利亚北部,和西非。传统上，该植物已被用作膏药的形式来治疗发烧。然而,没有关于其毒性特征的科学研究得到证实。
UNASSIGNED：已经进行了这项研究，以确定从鱼尾草叶中提取的甲醇提取物的潜在毒性，在小鼠中采用急性和亚慢性口服给药技术。
UNASSIGNED：在根据OECD指南425的急性毒性研究中，在两种性别的瑞士白化病小鼠中以2000和5000mg/kg的单剂量口服FM甲醇提取物。有毒症状,异常行为,体重的变化，和死亡率观察连续14天。在根据OECD指南407的亚慢性毒性研究中,植物提取物以每天100、500、1000和2000mg/kg的剂量口服施用28天。一般的中毒症状，异常行为,每天观察体重变化。血清生化分析,研究结束时进行肝脏组织病理学检查。
未经批准：无死亡，异常行为和排尿，睡眠的变化，食物摄入量,不利影响,在2000和5000mg/kg剂量的急性毒性研究中，已经记录了体重的非线性。此外，在亚慢性毒性研究中，FM提取物在一般行为方面没有产生死亡率或任何不利影响，体重,排尿,睡眠常规，和食物摄入。在分析十三个不同的生化参数的情况下，在急性和亚慢性研究中，雄性和雌性小鼠的天冬氨酸转氨酶（AST）和葡萄糖浓度均发生显着变化。总胆固醇和甘油三酯在5000mg/kg。在急性毒性研究中，雄性小鼠的bw发生变化。另一方面,雌性小鼠在亚慢性试验中改变了甘油三酯。发现所有其他关键参数未受影响。在亚慢性测试中，肝脏的组织病理学检查显示细胞坏死为2000mg/kg。bw在雄性和雌性小鼠中，而在1000mg/kg时观察到轻微的坏死。bw.因此，没有观察到的不良反应水平（NOAEL）可以假设在1000mg/kg左右。bw.
未经证实：本研究表明，用FM提取物治疗未显示出明显的毒性。
UNASSIGNED：已经进行了这项研究，以确定从鱼尾草叶中提取的甲醇提取物的潜在毒性，在小鼠中采用急性和亚慢性口服给药技术。
UNASSIGNED：在根据OECD指南425的急性毒性研究中，在两种性别的瑞士白化病小鼠中以2000和5000mg/kg的单剂量口服FM甲醇提取物。有毒症状,异常行为,体重的变化，和死亡率观察连续14天。在根据OECD指南407的亚慢性毒性研究中,植物提取物以每天100、500、1000和2000mg/kg的剂量口服施用28天。一般的中毒症状，异常行为,每天观察体重变化。血清生化分析,研究结束时进行肝脏组织病理学检查。
未经批准：无死亡，异常行为和排尿，睡眠的变化，食物摄入量,不利影响,在2000和5000mg/kg剂量的急性毒性研究中，已经记录了体重的非线性。此外，在亚慢性毒性研究中，FM提取物在一般行为方面没有产生死亡率或任何不利影响，体重,排尿,睡眠常规，和食物摄入。在分析十三个不同的生化参数的情况下，在急性和亚慢性研究中，雄性和雌性小鼠的天冬氨酸转氨酶（AST）和葡萄糖浓度均发生显着变化。总胆固醇和甘油三酯在5000mg/kg。在急性毒性研究中，雄性小鼠的bw发生变化。另一方面,雌性小鼠在亚慢性试验中改变了甘油三酯。发现所有其他关键参数未受影响。在亚慢性测试中，肝脏的组织病理学检查显示细胞坏死为2000mg/kg。bw在雄性和雌性小鼠中，而在1000mg/kg时观察到轻微的坏死。bw.因此，没有观察到的不良反应水平（NOAEL）可以假设在1000mg/kg左右。bw.
未经证实：本研究表明，用FM提取物治疗未显示出明显的毒性。
