Abstract：
Postmenopausal women often have chronic cough. Hormonal changes might be affecting lung function and the mucous membrane of the airways, causing hypersensitivity of the cough reflex. Therefore, postmenopausal hormonal changes could play a key role in the association between increased cough and menopause. The aim of this study is to evaluate the relation of chronic cough and postmenopausal symptoms.
We performed a questionnaire-based cohort study in generally healthy postmenopausal women (age 45-65 years). Women with cough explained by a pre-existing diagnosis were excluded. Comorbidities, medication and baseline data were collected. The Menopause Rating Scale II (MRS II) was combined with the Leicester Cough Questionnaire. Groups were divided in chronic cough versus non-coughing participants, chronic cough was defined as symptoms over 8 weeks. We performed correlations and logistic regression for predicting cough based on postmenopausal symptoms.
Sixty-six of 200 women (33%) reported symptoms of chronic cough over 8 weeks. No significant differences in baseline data (age, BMI, onset of menopause, years since menopause, concomitant diseases, and medication) were found between coughing and non-coughing women. The MRS II showed higher menopausal symptoms in patients with cough, with significant differences in 2 of the 3 MRS-domains (urogenital (p < 0.001) and somato-vegetative (p < 0.001)). Climacteric symptoms correlated strongly with parameters of cough (p < 0.001). On the basis of the MRS total score (p < 0.001) and the somato-vegetative and urogenital domains (p < 0.05), the prediction for respiratory complaints could be shown.
Chronic cough was significantly associated with menopausal symptoms. Therefore chronic cough as a possible climacteric symptom and its underlying mechanisms should be further explored.
We performed a questionnaire-based cohort study in generally healthy postmenopausal women (age 45-65 years). Women with cough explained by a pre-existing diagnosis were excluded. Comorbidities, medication and baseline data were collected. The Menopause Rating Scale II (MRS II) was combined with the Leicester Cough Questionnaire. Groups were divided in chronic cough versus non-coughing participants, chronic cough was defined as symptoms over 8 weeks. We performed correlations and logistic regression for predicting cough based on postmenopausal symptoms.
Sixty-six of 200 women (33%) reported symptoms of chronic cough over 8 weeks. No significant differences in baseline data (age, BMI, onset of menopause, years since menopause, concomitant diseases, and medication) were found between coughing and non-coughing women. The MRS II showed higher menopausal symptoms in patients with cough, with significant differences in 2 of the 3 MRS-domains (urogenital (p < 0.001) and somato-vegetative (p < 0.001)). Climacteric symptoms correlated strongly with parameters of cough (p < 0.001). On the basis of the MRS total score (p < 0.001) and the somato-vegetative and urogenital domains (p < 0.05), the prediction for respiratory complaints could be shown.
Chronic cough was significantly associated with menopausal symptoms. Therefore chronic cough as a possible climacteric symptom and its underlying mechanisms should be further explored.
摘要：
背景：绝经后妇女常有慢性咳嗽。激素变化可能会影响肺功能和气道粘膜，引起咳嗽反射的超敏反应。因此,绝经后荷尔蒙变化可能在咳嗽增加和绝经之间的关联中起关键作用.这项研究的目的是评估慢性咳嗽与绝经后症状的关系。
方法：我们在一般健康的绝经后妇女（年龄45-65岁）中进行了一项基于问卷调查的队列研究。排除由预先存在的诊断解释为咳嗽的妇女。合并症,收集用药和基线数据.更年期评定量表II（MRSII）与莱斯特咳嗽问卷相结合。分为慢性咳嗽和非咳嗽参与者，慢性咳嗽定义为超过8周的症状.我们根据绝经后症状进行相关性和逻辑回归预测咳嗽。
结果：200名女性中有66名（33%）报告了8周内的慢性咳嗽症状。基线数据无显着差异（年龄，BMI,更年期的开始，更年期多年来，伴随疾病，和药物）在咳嗽和非咳嗽妇女之间发现。MRSII在咳嗽患者中表现出更高的更年期症状，3个MRS域中的2个存在显着差异（泌尿生殖系统（p<0.001）和躯体营养体（p<0.001））。更年期症状与咳嗽参数密切相关（p<0.001）。根据MRS总分（p<0.001）和躯体营养和泌尿生殖领域（p<0.05），可以显示对呼吸道投诉的预测。
结论：慢性咳嗽与更年期症状显著相关。因此，应进一步探讨慢性咳嗽作为一种可能的更年期症状及其潜在机制。
方法：我们在一般健康的绝经后妇女（年龄45-65岁）中进行了一项基于问卷调查的队列研究。排除由预先存在的诊断解释为咳嗽的妇女。合并症,收集用药和基线数据.更年期评定量表II（MRSII）与莱斯特咳嗽问卷相结合。分为慢性咳嗽和非咳嗽参与者，慢性咳嗽定义为超过8周的症状.我们根据绝经后症状进行相关性和逻辑回归预测咳嗽。
结果：200名女性中有66名（33%）报告了8周内的慢性咳嗽症状。基线数据无显着差异（年龄，BMI,更年期的开始，更年期多年来，伴随疾病，和药物）在咳嗽和非咳嗽妇女之间发现。MRSII在咳嗽患者中表现出更高的更年期症状，3个MRS域中的2个存在显着差异（泌尿生殖系统（p<0.001）和躯体营养体（p<0.001））。更年期症状与咳嗽参数密切相关（p<0.001）。根据MRS总分（p<0.001）和躯体营养和泌尿生殖领域（p<0.05），可以显示对呼吸道投诉的预测。
结论：慢性咳嗽与更年期症状显著相关。因此，应进一步探讨慢性咳嗽作为一种可能的更年期症状及其潜在机制。
