Abstract：
To review the impact of contemporary treatment strategies on salvage outcomes in patients with recurrent human papilloma virus-positive oropharyngeal squamous cell carcinoma (HPV + OPSCC).
Secondary to HPV, changes in disease biology have impacted primary treatments and subsequent approaches to patients with recurrence. With treatment strategies more inclusive of upfront surgery, the characteristics of patients with recurrence HPV + OPSCC have been further redefined. Less invasive endoscopic surgical approaches such as transoral robotic surgery (TORS), and the continued refinement of conformal radiotherapy techniques, have improved treatment options for patients with recurrent HPV + OPSCC. Systemic treatment options have continued to expand including potentially effective immune-based therapies. Effective surveillance with systemic and oral biomarkers offers hope of earlier detection of recurrence. Management of patients with recurrent OPSCC remains difficult. Modest improvements in salvage treatment have been observed within the HPV + OPSCC cohort largely reflecting disease biology and improved treatment techniques.
Secondary to HPV, changes in disease biology have impacted primary treatments and subsequent approaches to patients with recurrence. With treatment strategies more inclusive of upfront surgery, the characteristics of patients with recurrence HPV + OPSCC have been further redefined. Less invasive endoscopic surgical approaches such as transoral robotic surgery (TORS), and the continued refinement of conformal radiotherapy techniques, have improved treatment options for patients with recurrent HPV + OPSCC. Systemic treatment options have continued to expand including potentially effective immune-based therapies. Effective surveillance with systemic and oral biomarkers offers hope of earlier detection of recurrence. Management of patients with recurrent OPSCC remains difficult. Modest improvements in salvage treatment have been observed within the HPV + OPSCC cohort largely reflecting disease biology and improved treatment techniques.
摘要：
目的：回顾当代治疗策略对复发性人乳头瘤病毒阳性口咽鳞状细胞癌（HPV+OPSCC）患者抢救结果的影响。
结果：继发于HPV，疾病生物学的变化影响了复发患者的主要治疗方法和后续治疗方法.随着治疗策略更加包括前期手术，HPV+OPSCC复发患者的特征被进一步重新定义.微创内窥镜手术方法，如经口机器人手术(TORS)，以及适形放射治疗技术的不断完善，改善了HPV+OPSCC复发患者的治疗选择。系统性治疗选择继续扩大，包括潜在有效的基于免疫的疗法。系统和口服生物标志物的有效监测为早期发现复发提供了希望。复发性OPSCC患者的治疗仍然很困难。在HPV+OPSCC队列中已经观察到挽救治疗的适度改善,这在很大程度上反映了疾病生物学和改进的治疗技术。
结果：继发于HPV，疾病生物学的变化影响了复发患者的主要治疗方法和后续治疗方法.随着治疗策略更加包括前期手术，HPV+OPSCC复发患者的特征被进一步重新定义.微创内窥镜手术方法，如经口机器人手术(TORS)，以及适形放射治疗技术的不断完善，改善了HPV+OPSCC复发患者的治疗选择。系统性治疗选择继续扩大，包括潜在有效的基于免疫的疗法。系统和口服生物标志物的有效监测为早期发现复发提供了希望。复发性OPSCC患者的治疗仍然很困难。在HPV+OPSCC队列中已经观察到挽救治疗的适度改善,这在很大程度上反映了疾病生物学和改进的治疗技术。
