UNASSIGNED: We conducted a nationwide retrospective matched cohort study from 1 April 2018 to 1 April 2021 using a linked de-identified patient level Ministry of Health data platform. A Cox proportional hazards model was used to estimate ZVL vaccine effectiveness (VE) against HZ and PHN adjusting for covariates. Multiple outcomes were assessed in the primary (hospitalised HZ and PHN - primary diagnosis) and secondary (hospitalised HZ and PHN: primary and secondary diagnosis, community HZ) analyses. A sub-group analysis was carried out in, adults ≥ 65 years old, immunocompromised adults, Māori, and Pacific populations.
UNASSIGNED: A total of 824,142 (274,272 vaccinated with ZVL matched with 549,870 unvaccinated) New Zealand residents were included in the study. The matched population was 93.4% immunocompetent, 52.2% female, 80.2% European (level 1 ethnic codes), and 64.5% were 65-74 years old (mean age = 71.1±5.0). Vaccinated versus unvaccinated incidence of hospitalised HZ was 0.16 vs. 0.31/1,000 person-years and 0.03 vs. 0.08/1000 person-years for PHN. In the primary analysis, the adjusted overall VE against hospitalised HZ and hospitalised PHN was 57.8% (95% CI: 41.1-69.8) and 73.7% (95% CI:14.0-92.0) respectively. In adults ≥ 65 years old, the VE against hospitalised HZ was 54.4% (95% CI: 36.0-67.5) and VE against hospitalised PHN was 75·5% (95% CI: 19.9-92.5). In the secondary analysis, the VE against community HZ was 30.0% (95% CI: 25.6-34.5). The ZVL VE against hospitalised HZ for immunocompromised adults was 51.1% (95% CI: 23.1-69.5), and PHN hospitalisation was 67.6% (95% CI: 9.3-88.4). The VE against HZ hospitalisation for Māori was 45.2% (95% CI: -23.2-75.6) and for Pacific Peoples was 52.2% (95% CI: -40.6 -83·7).
UNASSIGNED: ZVL was associated with a reduction in risk of hospitalisation from HZ and PHN in the New Zealand population.
UNASSIGNED: Wellington Doctoral Scholarship awarded to JFM.
UNASSIGNED:我们在2018年4月1日至2021年4月1日期间,使用联系的去识别患者级别的卫生部数据平台,进行了一项全国性的回顾性配对队列研究。Cox比例风险模型用于评估ZVL疫苗对HZ和PHN的有效性(VE),以调整协变量。在主要(住院HZ和PHN-主要诊断)和次要(住院HZ和PHN:主要和次要诊断,社区HZ)分析。进行了亚组分析,成年人≥65岁,免疫力低下的成年人,毛利人,太平洋人口。
UNASSIGNED:共有824,142名(与549,870名未接种疫苗的ZVL疫苗匹配的274,272名)新西兰居民被纳入研究。匹配人群的免疫能力为93.4%,52.2%女性,80.2%的欧洲(一级种族代码),65~74岁占64.5%(平均年龄71.1±5.0)。接种疫苗与未接种疫苗的住院HZ发生率为0.16vs.0.31/1000人年和0.03vs.PHN为0.08/1000人年。在初步分析中,针对住院HZ和住院PHN的校正总VE分别为57.8%(95%CI:41.1-69.8)和73.7%(95%CI:14.0-92.0).在≥65岁的成年人中,针对住院HZ的VE为54.4%(95%CI:36.0-67.5),针对住院PHN的VE为75·5%(95%CI:19.9-92.5)。在次要分析中,对社区HZ的VE为30.0%(95%CI:25.6-34.5)。免疫功能低下的成年人对住院HZ的ZVLVE为51.1%(95%CI:23.1-69.5),PHN住院率为67.6%(95%CI:9.3-88.4)。毛利人对HZ住院的VE为45.2%(95%CI:-23.2-75.6),太平洋人民为52.2%(95%CI:-40.6-83·7)。
UNASSIGNED:ZVL与新西兰人群HZ和PHN住院风险降低相关。
UNASSIGNED:惠灵顿博士奖学金授予JFM。