A Functional Polymorphism in IL-1B Is Associated With Immune Reconstitution Inflammatory Syndrome of Chronic Disseminated Candidiasis.

IL - 1B 的功能多态性与慢性播散性念珠菌病的免疫重建炎症综合征相关。

• 影响指数: 4.423
• 发表时间: Mar 2023
• 来源期刊: Open Forum Infect Dis
• DOI: 10.1093/ofid/ofad078
• PMID: 36879623
• 文章类型: Journal Article
• 中科院分区: Q3
• 方向: 医学
• 作者列表: Rammaert B,Bochud PY,Brunel AS,Wojtowicz A,Candon S,Gallego Hernanz MP,Lortholary O

关键词: Candida spp; IL-1B; cytokines; genetic polymorphism; immune inflammatory reconstitution syndrome; invasive fungal diseases

Abstract

We investigated single nucleotide polymorphisms (SNPs) possibly involved in immune reconstitution inflammatory syndrome of chronic disseminated candidiasis (IRIS-CDC) through a candidate gene approach and a prospective matched-control study. We found that an SNP located in interleukin-1B at rs1143627 was significantly associated with the risk of developing IRIS-CDC.

摘要

我们通过候选基因方法和前瞻性配对对照研究，研究了可能与慢性播散性念珠菌病（IRIS-CDC）的免疫重建炎症综合征有关的单核苷酸多态性（SNP）。我们发现，位于白细胞介素-1B的SNPrs1143627与发展IRIS-CDC的风险显着相关。