Abstract：
Obesity is a disease with a major negative impact on human health. However, people with obesity may not perceive their weight to be a significant problem and less than half of patients with obesity are advised by their physicians to lose weight. The purpose of this review is to highlight the importance of managing overweight and obesity by discussing the adverse consequences and impact of obesity. In summary, obesity is strongly related to >50 medical conditions, with many of them having evidence from Mendelian randomisation studies to support causality. The clinical, social and economic burdens of obesity are considerable, with these burdens potentially impacting future generations as well. This review highlights the adverse health and economic consequences of obesity and the importance of an urgent and concerted effort towards the prevention and management of obesity to reduce the burden of obesity.
摘要：
肥胖是一种对人类健康有重大负面影响的疾病。然而,肥胖患者可能不会认为他们的体重是一个严重的问题，不到一半的肥胖患者被医生建议减肥。这篇综述的目的是通过讨论肥胖的不利后果和影响来强调管理超重和肥胖的重要性。总之,肥胖与>50的医疗条件密切相关，他们中的许多人都有孟德尔随机化研究的证据支持因果关系。临床，肥胖的社会和经济负担相当大，这些负担也可能影响后代。这篇综述强调了肥胖对健康和经济的不利影响，以及对预防和管理肥胖以减轻肥胖负担的紧急和协调努力的重要性。
