PDF(Pubmed)
Abstract：
Plasmablastic lymphoma (PBL) is a rare form of lymphoma in people. PBL originates from plasmablasts and usually presents with swelling/mass in the mouth/neck. A 7-year-old Mongrel dog was presented for a large oral and neck mass. Cytology and histopathology were suggestive of a round cell tumor that was suspected to be lymphoma. An immunohistochemical (IHC) stain panel showed positive for CD18, thus supporting the diagnosis of round cell tumor, but negative for T- and B-cell lymphomas, CD3, CD20, and PAX-5. Other markers including cytokeratin AE1/3 (for epithelial cell origin), CD31 (for endothelial cells), SOX10 (for melanoma), IBa-1 (for histiocytic sarcoma), and CD117 (for mast cell tumor) were all negative. MUM-1 (for plasma cell differentiation) was strongly positive and CD79a (B cell and plasma cells) was also scantly positive. Based on the histopathology and immunohistochemistry results in combination with the clinical presentation, a suspected diagnosis of PBL was made. As per available literature, this is perhaps the first highly suspected case of PBL in a dog.
摘要：
成浆细胞淋巴瘤（PBL）是人类罕见的淋巴瘤形式。PBL起源于成浆细胞，通常在口腔/颈部出现肿胀/肿块。一只7岁的杂种狗因口腔和颈部肿块而出现。细胞学和组织病理学提示圆形细胞肿瘤，怀疑是淋巴瘤。免疫组织化学（IHC）染色面板显示CD18阳性，因此支持圆形细胞肿瘤的诊断，但T细胞和B细胞淋巴瘤阴性,CD3、CD20和PAX-5。其他标志物包括细胞角蛋白AE1/3（用于上皮细胞来源），CD31（内皮细胞），SOX10（用于黑色素瘤），IBa-1（用于组织细胞肉瘤），CD117（肥大细胞瘤）均为阴性。MUM-1(用于浆细胞分化)是强阳性的,并且CD79a(B细胞和浆细胞)也是少量阳性的。根据组织病理学和免疫组织化学结果结合临床表现，有可疑的PBL诊断.根据现有文献，这可能是第一例被怀疑为PBL的狗。
