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Abstract：
To investigate the application value of 3T MRI qDixon-WIP technique in the quantitative measurement of pancreatic fat content in patients with type 2 diabetes mellitus (T2DM).
The 3T MRI qDixon-WIP sequence was used to scan the livers and the pancreas of 47 T2DM patients (experimental group) and 48 healthy volunteers (control group). Pancreatic fat fraction (PFF), hepatic fat fraction (HFF), Body mass index (BMI) ratio of pancreatic volume to body surface area (PVI) were measured. Total cholesterol (TC), subcutaneous fat area (SA), triglyceride (TG), abdominal visceral fat area (VA), high density lipoprotein (HDL-c), fasting blood glucose (FPC) and low-density lipoprotein (LDL-c) were collected. The relationship between the experimental group and the control group and between PFF and other indicators was compared. The differences of PFF between the control group and different disease course subgroups were also explored.
There was no significant difference in BMI between the experimental group and the control group (P=0.231). PVI, SA, VA, PFF and HFF had statistical differences (P<0.05). In the experimental group, PFF was highly positively correlated with HFF (r=0.964, P<0.001), it was moderately positively correlated with TG and abdominal fat area (r=0.676, 0.591, P<0.001), and it was weakly positively correlated with subcutaneous fat area (r=0.321, P=0.033). And it had no correlation with FPC, PVI, HDL-c, TC and LDL-c (P>0.05). There were statistical differences in PFF between the control group and the patients with different course of T2DM (P<0.05). There was no significant difference in PFF between T2DM patients with a disease course ≤1 year and those with a disease course <5 years (P>0.05). There were significant differences in PFF between the groups with a disease course of 1-5 years and those with a disease course of more than 5 years (P<0.001).
PVI of T2DM patients is lower than normal, but SA, VA, PFF, HFF are higher than normal. The degree of pancreatic fat accumulation in T2DM patients with long disease course was higher than that in patients with short disease course. The qDixon-WIP sequence can provide an important reference for clinical quantitative evaluation of fat content in T2DM patients.
The 3T MRI qDixon-WIP sequence was used to scan the livers and the pancreas of 47 T2DM patients (experimental group) and 48 healthy volunteers (control group). Pancreatic fat fraction (PFF), hepatic fat fraction (HFF), Body mass index (BMI) ratio of pancreatic volume to body surface area (PVI) were measured. Total cholesterol (TC), subcutaneous fat area (SA), triglyceride (TG), abdominal visceral fat area (VA), high density lipoprotein (HDL-c), fasting blood glucose (FPC) and low-density lipoprotein (LDL-c) were collected. The relationship between the experimental group and the control group and between PFF and other indicators was compared. The differences of PFF between the control group and different disease course subgroups were also explored.
There was no significant difference in BMI between the experimental group and the control group (P=0.231). PVI, SA, VA, PFF and HFF had statistical differences (P<0.05). In the experimental group, PFF was highly positively correlated with HFF (r=0.964, P<0.001), it was moderately positively correlated with TG and abdominal fat area (r=0.676, 0.591, P<0.001), and it was weakly positively correlated with subcutaneous fat area (r=0.321, P=0.033). And it had no correlation with FPC, PVI, HDL-c, TC and LDL-c (P>0.05). There were statistical differences in PFF between the control group and the patients with different course of T2DM (P<0.05). There was no significant difference in PFF between T2DM patients with a disease course ≤1 year and those with a disease course <5 years (P>0.05). There were significant differences in PFF between the groups with a disease course of 1-5 years and those with a disease course of more than 5 years (P<0.001).
PVI of T2DM patients is lower than normal, but SA, VA, PFF, HFF are higher than normal. The degree of pancreatic fat accumulation in T2DM patients with long disease course was higher than that in patients with short disease course. The qDixon-WIP sequence can provide an important reference for clinical quantitative evaluation of fat content in T2DM patients.
摘要：
UNASSIGNED：探讨3TMRIqDixon-WIP技术在2型糖尿病（T2DM）患者胰腺脂肪含量定量测量中的应用价值。
UNASSIGNED：使用3TMRIqDixon-WIP序列扫描47名T2DM患者（实验组）和48名健康志愿者（对照组）的肝脏和胰腺。胰腺脂肪分数（PFF），肝脂肪分数（HFF），测量胰腺体积与体表面积（PVI）的体重指数（BMI）比率。总胆固醇(TC),皮下脂肪面积(SA),甘油三酯（TG），腹部内脏脂肪面积（VA），高密度脂蛋白（HDL-c），收集空腹血糖（FPC）和低密度脂蛋白（LDL-c）。比较实验组与对照组之间以及PFF与其他指标之间的关系。还探讨了对照组和不同病程亚组之间PFF的差异。
UNASSIGNED：实验组与对照组之间的BMI没有显着差异（P=0.231）。PVI,SA,VA,PFF和HFF差异有统计学意义(P<0.05)。在实验组中,PFF与HFF呈高度正相关(r=0.964,P<0.001),与TG、腹部脂肪面积呈中度正相关(r=0.676,0.591,P<0.001),与皮下脂肪面积呈微弱正相关(r=0.321,P=0.033)。它与FPC没有相关性，PVI,HDL-c,TC和LDL-c(P>0.05)。对照组与不同病程T2DM患者的PFF比较差异有统计学意义(P<0.05)。病程≤1年的T2DM患者与病程<5年的T2DM患者的PFF比较,差异无统计学意义(P>0.05)。病程1～5年与病程5年以上组的PFF差异有统计学意义(P<0.001)。
UNASSIGNED：T2DM患者的PVI低于正常，但是SA,VA,PFF,HFF高于正常值。病程长的T2DM患者胰腺脂肪堆积程度高于病程短的患者。qDixon-WIP序列可为临床定量评价T2DM患者脂肪含量提供重要参考。
UNASSIGNED：使用3TMRIqDixon-WIP序列扫描47名T2DM患者（实验组）和48名健康志愿者（对照组）的肝脏和胰腺。胰腺脂肪分数（PFF），肝脂肪分数（HFF），测量胰腺体积与体表面积（PVI）的体重指数（BMI）比率。总胆固醇(TC),皮下脂肪面积(SA),甘油三酯（TG），腹部内脏脂肪面积（VA），高密度脂蛋白（HDL-c），收集空腹血糖（FPC）和低密度脂蛋白（LDL-c）。比较实验组与对照组之间以及PFF与其他指标之间的关系。还探讨了对照组和不同病程亚组之间PFF的差异。
UNASSIGNED：实验组与对照组之间的BMI没有显着差异（P=0.231）。PVI,SA,VA,PFF和HFF差异有统计学意义(P<0.05)。在实验组中,PFF与HFF呈高度正相关(r=0.964,P<0.001),与TG、腹部脂肪面积呈中度正相关(r=0.676,0.591,P<0.001),与皮下脂肪面积呈微弱正相关(r=0.321,P=0.033)。它与FPC没有相关性，PVI,HDL-c,TC和LDL-c(P>0.05)。对照组与不同病程T2DM患者的PFF比较差异有统计学意义(P<0.05)。病程≤1年的T2DM患者与病程<5年的T2DM患者的PFF比较,差异无统计学意义(P>0.05)。病程1～5年与病程5年以上组的PFF差异有统计学意义(P<0.001)。
UNASSIGNED：T2DM患者的PVI低于正常，但是SA,VA,PFF,HFF高于正常值。病程长的T2DM患者胰腺脂肪堆积程度高于病程短的患者。qDixon-WIP序列可为临床定量评价T2DM患者脂肪含量提供重要参考。
