PDF(Pubmed)
Abstract：
UNASSIGNED: We evaluate the impact of test target location in assessing rod-mediated dark adaptation (RMDA) along the transition from normal aging to intermediate age-related macular degeneration (AMD). We consider whether RMDA slows because the test locations are near mechanisms leading to or resulting from high-risk extracellular deposits. Soft drusen cluster under the fovea and extend to the inner ring of the ETDRS grid where rods are sparse. Subretinal drusenoid deposits (SDDs) appear first in the outer superior subfield of the ETDRS grid where rod photoreceptors are maximal and spread toward the fovea without covering it.
UNASSIGNED: Cross-sectional.
UNASSIGNED: Adults ≥ 60 years with normal older maculas, early AMD, or intermediate AMD as defined by the Age-Related Eye Disease Study (AREDS) 9-step and Beckman grading systems.
UNASSIGNED: In 1 eye per participant, RMDA was assessed at 5° and at 12° in the superior retina. Subretinal drusenoid deposit presence was identified with multi-modal imaging.
UNASSIGNED: Rod intercept time (RIT) as a measure of RMDA rate at 5° and 12°.
UNASSIGNED: In 438 eyes of 438 persons, RIT was significantly longer (i.e., RMDA is slower) at 5° than at 12° for each AMD severity group. Differences among groups were bigger at 5° than at 12°. At 5°, SDD presence was associated with longer RIT as compared to SDD absence at early and intermediate AMD but not in normal eyes. At 12°, SDD presence was associated with longer RIT in intermediate AMD only, and not in normal or early AMD eyes. Findings were similar in eyes stratified by AREDS 9-step and Beckman systems.
UNASSIGNED: We probed RMDA in relation to current models of deposit-driven AMD progression organized around photoreceptor topography. In eyes with SDD, slowed RMDA occurs at 5° where these deposits typically do not appear until later in AMD. Even in eyes lacking detectable SDD, RMDA at 5° is slower than at 12°. The effect at 5° may be attributed to mechanisms associated with the accumulation of soft drusen and precursors under the macula lutea throughout adulthood. These data will facilitate the design of efficient clinical trials for interventions that aim to delay AMD progression.
UNASSIGNED: Cross-sectional.
UNASSIGNED: Adults ≥ 60 years with normal older maculas, early AMD, or intermediate AMD as defined by the Age-Related Eye Disease Study (AREDS) 9-step and Beckman grading systems.
UNASSIGNED: In 1 eye per participant, RMDA was assessed at 5° and at 12° in the superior retina. Subretinal drusenoid deposit presence was identified with multi-modal imaging.
UNASSIGNED: Rod intercept time (RIT) as a measure of RMDA rate at 5° and 12°.
UNASSIGNED: In 438 eyes of 438 persons, RIT was significantly longer (i.e., RMDA is slower) at 5° than at 12° for each AMD severity group. Differences among groups were bigger at 5° than at 12°. At 5°, SDD presence was associated with longer RIT as compared to SDD absence at early and intermediate AMD but not in normal eyes. At 12°, SDD presence was associated with longer RIT in intermediate AMD only, and not in normal or early AMD eyes. Findings were similar in eyes stratified by AREDS 9-step and Beckman systems.
UNASSIGNED: We probed RMDA in relation to current models of deposit-driven AMD progression organized around photoreceptor topography. In eyes with SDD, slowed RMDA occurs at 5° where these deposits typically do not appear until later in AMD. Even in eyes lacking detectable SDD, RMDA at 5° is slower than at 12°. The effect at 5° may be attributed to mechanisms associated with the accumulation of soft drusen and precursors under the macula lutea throughout adulthood. These data will facilitate the design of efficient clinical trials for interventions that aim to delay AMD progression.
摘要：
UNASSIGNED：我们评估了测试目标位置在评估从正常老化到中间年龄相关性黄斑变性（AMD）的过渡过程中的杆介导的暗适应（RMDA）的影响。我们考虑RMDA是否会减慢，因为测试位置接近导致或由高风险细胞外沉积引起的机制。软玻璃疣聚集在中央凹下方，并延伸到ETDRS网格的内环，其中杆稀疏。视网膜下树状软骨样沉积物（SDDs）首先出现在ETDRS网格的外部上子域中，在该子域中，杆状光感受器最大，并向中央凹扩散而不覆盖它。
未经评估：横截面。
未经评估：成年人≥60岁，有正常的老年黄斑，早期AMD,或年龄相关性眼病研究（AREDS）9步和Beckman分级系统定义的中度AMD。
未经评估：每个参与者1只眼睛，在上视网膜中在5°和12°评估RMDA。通过多模态成像确定了视网膜下的神经壶样沉积物的存在。
UNASSIGNED：杆截取时间（RIT）作为5°和12°时RMDA速率的量度。
未经授权：在438人的438只眼睛中，RIT明显更长(即，对于每个AMD严重程度组，RMDA在5°处比在12°处慢）。5°组之间的差异大于12°组之间的差异。5°时,与早期和中期AMD的SDD缺失相比，SDD的存在与较长的RIT相关，但在正常眼中并非如此。在12°时,仅在中度AMD中，SDD的存在与较长的RIT相关，而不是在正常或早期AMD的眼睛。通过AREDS9步和Beckman系统分层的眼睛发现相似。
UNASSIGNED：我们探讨了RMDA与当前围绕光感受器形貌组织的沉积物驱动AMD进展模型的关系。在SDD的眼中，缓慢的RMDA发生在5°，这些沉积物通常直到AMD后期才出现。即使在缺乏可检测的SDD的眼睛中，5°时的RMDA比12°时慢。5°的作用可能归因于与整个成年期黄斑下软性玻璃疣和前体积累有关的机制。这些数据将有助于设计旨在延缓AMD进展的干预措施的有效临床试验。
未经评估：横截面。
未经评估：成年人≥60岁，有正常的老年黄斑，早期AMD,或年龄相关性眼病研究（AREDS）9步和Beckman分级系统定义的中度AMD。
未经评估：每个参与者1只眼睛，在上视网膜中在5°和12°评估RMDA。通过多模态成像确定了视网膜下的神经壶样沉积物的存在。
UNASSIGNED：杆截取时间（RIT）作为5°和12°时RMDA速率的量度。
未经授权：在438人的438只眼睛中，RIT明显更长(即，对于每个AMD严重程度组，RMDA在5°处比在12°处慢）。5°组之间的差异大于12°组之间的差异。5°时,与早期和中期AMD的SDD缺失相比，SDD的存在与较长的RIT相关，但在正常眼中并非如此。在12°时,仅在中度AMD中，SDD的存在与较长的RIT相关，而不是在正常或早期AMD的眼睛。通过AREDS9步和Beckman系统分层的眼睛发现相似。
UNASSIGNED：我们探讨了RMDA与当前围绕光感受器形貌组织的沉积物驱动AMD进展模型的关系。在SDD的眼中，缓慢的RMDA发生在5°，这些沉积物通常直到AMD后期才出现。即使在缺乏可检测的SDD的眼睛中，5°时的RMDA比12°时慢。5°的作用可能归因于与整个成年期黄斑下软性玻璃疣和前体积累有关的机制。这些数据将有助于设计旨在延缓AMD进展的干预措施的有效临床试验。
