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Abstract：
Iron deficiency anemia is the most common extraintestinal symptom in patients with colorectal cancer (CRC). Inflammation associated with malignancy leads to functional iron deficiency via the hepcidin pathway, whereas chronic blood loss causes absolute iron deficiency and depletion of iron stores. The assessment and treatment of preoperative anemia is of great importance in patients with CRC, since published data have consistently shown that preoperative anemia is associated with increased need for perioperative blood transfusions and more postoperative complications. Recent studies have documented mixed results regarding the preoperative intravenous iron administration in anemic CRC patients in terms of efficacy for anemia correction, cost-effectiveness, need for transfusions and risk for postoperative complications.
摘要：
缺铁性贫血是结直肠癌（CRC）患者最常见的肠外症状。与恶性肿瘤相关的炎症通过hepcidin途径导致功能性铁缺乏，而慢性失血会导致绝对缺铁和铁储备耗尽。术前贫血的评估和治疗对CRC患者具有重要意义。由于已发表的数据一致表明，术前贫血与围手术期输血需求增加和术后并发症增多相关。最近的研究已经记录了关于贫血CRC患者术前静脉铁剂给药对贫血纠正的疗效的混合结果。成本效益，需要输血和术后并发症的风险。
