PDF(Pubmed)
Abstract：
Ondansetron is commonly used during the peri-operative period for the prophylaxis of postoperative nausea and vomiting (PONV). It is a 5-hydroxytryptamine 3 (5-HT3) receptor antagonist. Although relatively safe, few cases of ondansetron-induced bradycardia are described in the literature. Here, we present the case of a 41-year-old female with a burst fracture of the lumbar (L2) vertebrae following a fall from height. The patient underwent spinal fixation in the prone position. The intra-operative period was otherwise uneventful, except for an unprecedented incidence of bradycardia and hypotension following administration of intravenous (IV) ondansetron, at the time of closure of the surgical wound site. It was managed with IV atropine and fluid bolus. The patient was shifted to a intensive care unit (ICU) postoperatively. The postoperative period was uneventful, and the patient was discharged in good health on postoperative day three.
摘要：
昂丹司琼通常在围手术期用于预防术后恶心和呕吐（PONV）。它是5-羟色胺3（5-HT3）受体拮抗剂。虽然相对安全,文献中描述了很少的昂丹司琼诱导的心动过缓病例。这里,我们介绍了一名41岁的女性从高处跌落后腰椎（L2）爆裂骨折的情况。患者在俯卧位接受脊柱固定。术中期间否则平安无事，除了在静脉注射（IV）昂丹司琼后出现前所未有的心动过缓和低血压，在手术伤口部位闭合时。通过静脉阿托品和液体推注进行管理。患者术后被转移到重症监护病房（ICU）。术后期间平安无事,病人在术后第三天健康出院。
