PDF(Pubmed)
Abstract：
The incidence of major depressive disorder (MDD) is increasing all over the world. There is a great need for complementary or alternative therapies with high safety, few side effects, and precise efficacy to care for MDD. In China, acupuncture has significant laboratory data and clinical trials to demonstrate its antidepressant efficacy. However, there is no clear answer as to how it works. Exosomes are membranous vesicles that rely on cellular multivesicular bodies (MVBs) fused to the cell membrane for release into the extracellular matrix. Almost all cell types are capable of producing and releasing exosomes. As a result, exosomes contain complex RNAs and proteins from their relatives (Cells that secretes exosomes). They can cross biological barriers and participate in biological activities, such as cell migration, angiogenesis, and immune regulation. These properties have made them a popular research topic. Some experts have suggested that exosomes may serve as delivery vehicles for acupuncture to work. This presents both an opportunity and a new challenge for improving the protocols of acupuncture as a treatment for MDD. To better define the relationship between MDD, exosomes, and acupuncture, we reviewed the literature from the last few years. Inclusion criteria included randomized controlled trials and basic trials evaluating acupuncture in the treatment or prevention of MDD, the role of exosomes in the development and progression of MDD, and the role of exosomes in acupuncture. We believe that acupuncture may affect the distribution of exosomes in vivo, and exosomes may be a new carrier for acupuncture treatment of MDD in the future.
摘要：
在全世界范围内,重度抑郁症(MDD)的发病率呈上升趋势。非常需要具有高安全性的补充或替代疗法，副作用少,和精确的疗效来照顾MDD。在中国,针灸有重要的实验室数据和临床试验证明其抗抑郁疗效。然而,关于它是如何工作的，没有明确的答案。外来体是膜囊泡,其依赖于融合到细胞膜上的细胞多囊泡(MVB)以释放到细胞外基质中。几乎所有细胞类型都能够产生和释放外来体。因此,外泌体含有来自其亲属的复杂RNA和蛋白质(分泌外泌体的细胞)。它们可以跨越生物屏障，参与生物活动，如细胞迁移，血管生成,和免疫调节。这些性质使它们成为一个热门的研究课题。一些专家建议，外泌体可以作为针灸工作的输送载体。这为改善针灸治疗MDD的方案提供了机遇和新挑战。为了更好地定义MDD之间的关系，外泌体,和针灸，我们回顾了过去几年的文献。纳入标准包括随机对照试验和评估针灸治疗或预防MDD的基础试验。外泌体在MDD发生和进展中的作用，以及外泌体在针灸中的作用。我们认为针刺可能影响外泌体在体内的分布,外泌体可能是未来针灸治疗MDD的新载体。
