UNASSIGNED: A total of 8,768 Japanese patients with PBC were enrolled between 1980 and 2016 from 469 institutions, among whom 83% received ursodeoxycholic acid (UDCA) only, 9% received UDCA and bezafibrate, and 8% were given neither drug. Baseline clinical and laboratory parameters were retrospectively retrieved and reviewed from a central database. Associations of ALBI score/grade with histological stage, mortality, and need for liver transplantation (LT) were evaluated using Cox proportional hazards models.
UNASSIGNED: During the median follow-up period of 5.3 years, 1,227 patients died (including 789 from liver-related causes) and 113 underwent LT. ALBI score and ALBI grade were significantly associated with Scheuer\'s classification (both p <0.0001). ALBI grade 2 or 3 had significant associations with all-cause mortality or need for LT as well as liver-related mortality or need for LT according to Cox proportional hazards regression analysis (hazard ratio 3.453, 95% CI 2.942-4.052 and hazard ratio 4.242, 95% CI 3.421-5.260, respectively; both p <0.0001). Cumulative LT-free survival rates at 5 years in the ALBI grade 1, 2, and 3 groups were 97.2%, 82.4%, and 38.8%, respectively, while respective non-liver-related survival rates were 98.1%, 86.0%, and 42.0% (both p <0.0001, log-rank test).
UNASSIGNED: This large nationwide study of patients with PBC suggested that baseline measurements of ALBI grade were a simple non-invasive predictor of prognosis in PBC.
UNASSIGNED: Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by progressive destruction of intrahepatic bile ducts. This study examined the ability of albumin-bilirubin (ALBI) score/grade to estimate histological findings and disease progression in PBC by means of a large-scale nationwide cohort in Japan. ALBI score/grade were significantly associated with Scheuer\'s classification stage. Baseline ALBI grade measurements may be a simple non-invasive predictor of prognosis in PBC.
UNASSIGNED:1980年至2016年期间,从469个机构中招募了8,768名日本PBC患者。其中83%只接受熊去氧胆酸(UDCA),9%接受了UDCA和苯扎贝特,8%的人没有服用任何药物。回顾性地从中央数据库检索和审查基线临床和实验室参数。ALBI评分/分级与组织学分期的关联,死亡率,使用Cox比例风险模型评估肝移植的需要。
未经评估:在5.3年的中位随访期间,1,227例患者死亡(包括789例因肝脏相关原因死亡),113例接受LT。ALBI评分和ALBI分级与Scheuer分类显著相关(p均<0.0001)。根据Cox比例风险回归分析,ALBI2级或3级与全因死亡率或需要LT以及肝脏相关死亡率或需要LT显著相关(风险比3.453,95%CI2.942-4.052和风险比4.242,95%CI3.421-5.260;两者均p<0.0001)。ALBI1、2和3级组的5年累积无LT生存率为97.2%,82.4%,38.8%,分别,而各自的非肝脏相关生存率为98.1%,86.0%,和42.0%(均p<0.0001,对数秩检验)。
UNASSIGNED:这项针对PBC患者的大型全国性研究表明,ALBI分级的基线测量是PBC预后的简单非侵入性预测指标。
未经证实:原发性胆汁性胆管炎(PBC)是一种自身免疫性肝病,其特征是肝内胆管进行性破坏。这项研究通过日本的大规模全国性队列研究了白蛋白-胆红素(ALBI)评分/等级评估PBC组织学发现和疾病进展的能力。ALBI评分/等级与Scheuer分类阶段显著相关。基线ALBI等级测量可能是PBC预后的简单非侵入性预测指标。