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Abstract：
UNASSIGNED: The albumin-bilirubin (ALBI) score is calculated using serum levels of total bilirubin and albumin as a simple method to assess liver function. This study investigated the ability of baseline ALBI score/grade measurements to assess histological stage and disease progression in individuals with primary biliary cholangitis (PBC) in a large Japanese nationwide cohort.
UNASSIGNED: A total of 8,768 Japanese patients with PBC were enrolled between 1980 and 2016 from 469 institutions, among whom 83% received ursodeoxycholic acid (UDCA) only, 9% received UDCA and bezafibrate, and 8% were given neither drug. Baseline clinical and laboratory parameters were retrospectively retrieved and reviewed from a central database. Associations of ALBI score/grade with histological stage, mortality, and need for liver transplantation (LT) were evaluated using Cox proportional hazards models.
UNASSIGNED: During the median follow-up period of 5.3 years, 1,227 patients died (including 789 from liver-related causes) and 113 underwent LT. ALBI score and ALBI grade were significantly associated with Scheuer\'s classification (both p <0.0001). ALBI grade 2 or 3 had significant associations with all-cause mortality or need for LT as well as liver-related mortality or need for LT according to Cox proportional hazards regression analysis (hazard ratio 3.453, 95% CI 2.942-4.052 and hazard ratio 4.242, 95% CI 3.421-5.260, respectively; both p <0.0001). Cumulative LT-free survival rates at 5 years in the ALBI grade 1, 2, and 3 groups were 97.2%, 82.4%, and 38.8%, respectively, while respective non-liver-related survival rates were 98.1%, 86.0%, and 42.0% (both p <0.0001, log-rank test).
UNASSIGNED: This large nationwide study of patients with PBC suggested that baseline measurements of ALBI grade were a simple non-invasive predictor of prognosis in PBC.
UNASSIGNED: Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by progressive destruction of intrahepatic bile ducts. This study examined the ability of albumin-bilirubin (ALBI) score/grade to estimate histological findings and disease progression in PBC by means of a large-scale nationwide cohort in Japan. ALBI score/grade were significantly associated with Scheuer\'s classification stage. Baseline ALBI grade measurements may be a simple non-invasive predictor of prognosis in PBC.
UNASSIGNED: A total of 8,768 Japanese patients with PBC were enrolled between 1980 and 2016 from 469 institutions, among whom 83% received ursodeoxycholic acid (UDCA) only, 9% received UDCA and bezafibrate, and 8% were given neither drug. Baseline clinical and laboratory parameters were retrospectively retrieved and reviewed from a central database. Associations of ALBI score/grade with histological stage, mortality, and need for liver transplantation (LT) were evaluated using Cox proportional hazards models.
UNASSIGNED: During the median follow-up period of 5.3 years, 1,227 patients died (including 789 from liver-related causes) and 113 underwent LT. ALBI score and ALBI grade were significantly associated with Scheuer\'s classification (both p <0.0001). ALBI grade 2 or 3 had significant associations with all-cause mortality or need for LT as well as liver-related mortality or need for LT according to Cox proportional hazards regression analysis (hazard ratio 3.453, 95% CI 2.942-4.052 and hazard ratio 4.242, 95% CI 3.421-5.260, respectively; both p <0.0001). Cumulative LT-free survival rates at 5 years in the ALBI grade 1, 2, and 3 groups were 97.2%, 82.4%, and 38.8%, respectively, while respective non-liver-related survival rates were 98.1%, 86.0%, and 42.0% (both p <0.0001, log-rank test).
UNASSIGNED: This large nationwide study of patients with PBC suggested that baseline measurements of ALBI grade were a simple non-invasive predictor of prognosis in PBC.
UNASSIGNED: Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by progressive destruction of intrahepatic bile ducts. This study examined the ability of albumin-bilirubin (ALBI) score/grade to estimate histological findings and disease progression in PBC by means of a large-scale nationwide cohort in Japan. ALBI score/grade were significantly associated with Scheuer\'s classification stage. Baseline ALBI grade measurements may be a simple non-invasive predictor of prognosis in PBC.
摘要：
UNASSIGNED：使用血清总胆红素和白蛋白水平作为评估肝功能的简单方法来计算白蛋白-胆红素（ALBI）评分。这项研究调查了基线ALBI评分/等级测量在日本全国大型队列中评估原发性胆汁性胆管炎（PBC）个体的组织学阶段和疾病进展的能力。
UNASSIGNED：1980年至2016年期间，从469个机构中招募了8,768名日本PBC患者。其中83%只接受熊去氧胆酸(UDCA)，9%接受了UDCA和苯扎贝特，8%的人没有服用任何药物。回顾性地从中央数据库检索和审查基线临床和实验室参数。ALBI评分/分级与组织学分期的关联，死亡率,使用Cox比例风险模型评估肝移植的需要。
未经评估：在5.3年的中位随访期间，1,227例患者死亡（包括789例因肝脏相关原因死亡），113例接受LT。ALBI评分和ALBI分级与Scheuer分类显著相关(p均<0.0001)。根据Cox比例风险回归分析，ALBI2级或3级与全因死亡率或需要LT以及肝脏相关死亡率或需要LT显著相关（风险比3.453，95％CI2.942-4.052和风险比4.242，95％CI3.421-5.260；两者均p<0.0001）。ALBI1、2和3级组的5年累积无LT生存率为97.2％，82.4%,38.8%,分别,而各自的非肝脏相关生存率为98.1%，86.0%,和42.0%(均p<0.0001，对数秩检验)。
UNASSIGNED：这项针对PBC患者的大型全国性研究表明，ALBI分级的基线测量是PBC预后的简单非侵入性预测指标。
未经证实：原发性胆汁性胆管炎（PBC）是一种自身免疫性肝病，其特征是肝内胆管进行性破坏。这项研究通过日本的大规模全国性队列研究了白蛋白-胆红素（ALBI）评分/等级评估PBC组织学发现和疾病进展的能力。ALBI评分/等级与Scheuer分类阶段显著相关。基线ALBI等级测量可能是PBC预后的简单非侵入性预测指标。
UNASSIGNED：1980年至2016年期间，从469个机构中招募了8,768名日本PBC患者。其中83%只接受熊去氧胆酸(UDCA)，9%接受了UDCA和苯扎贝特，8%的人没有服用任何药物。回顾性地从中央数据库检索和审查基线临床和实验室参数。ALBI评分/分级与组织学分期的关联，死亡率,使用Cox比例风险模型评估肝移植的需要。
未经评估：在5.3年的中位随访期间，1,227例患者死亡（包括789例因肝脏相关原因死亡），113例接受LT。ALBI评分和ALBI分级与Scheuer分类显著相关(p均<0.0001)。根据Cox比例风险回归分析，ALBI2级或3级与全因死亡率或需要LT以及肝脏相关死亡率或需要LT显著相关（风险比3.453，95％CI2.942-4.052和风险比4.242，95％CI3.421-5.260；两者均p<0.0001）。ALBI1、2和3级组的5年累积无LT生存率为97.2％，82.4%,38.8%,分别,而各自的非肝脏相关生存率为98.1%，86.0%,和42.0%(均p<0.0001，对数秩检验)。
UNASSIGNED：这项针对PBC患者的大型全国性研究表明，ALBI分级的基线测量是PBC预后的简单非侵入性预测指标。
未经证实：原发性胆汁性胆管炎（PBC）是一种自身免疫性肝病，其特征是肝内胆管进行性破坏。这项研究通过日本的大规模全国性队列研究了白蛋白-胆红素（ALBI）评分/等级评估PBC组织学发现和疾病进展的能力。ALBI评分/等级与Scheuer分类阶段显著相关。基线ALBI等级测量可能是PBC预后的简单非侵入性预测指标。
