PDF(Pubmed)
Abstract：
To better understand zinc and copper regulation and their involvement in various biochemical pathways as it relates to autism spectrum disorder (ASD), isotopic composition of serum zinc and copper were evaluated in both healthy children and children with ASD in North America. No significant difference in isotopic composition of serum zinc or copper with respect to healthy controls and ASD children were identified. However, the isotopic composition of serum copper in boys was found to be enriched in 65Cu in comparison to previously published healthy adult copper isotopic composition. Furthermore, in both boys and girls, the average isotopic composition of serum zinc is heavier than previously published healthy adult isotopic zinc composition. There was also a negative association between total zinc concentrations in serum and the zinc isotopic composition of serum in boys. Finally, children with heavier isotopic composition of copper also showed a high degree of variability in their zinc isotopic composition. While numerous studies have measured the isotopic composition of serum zinc and copper in adults, this is one of the first studies which measured the isotopic composition of serum copper and zinc in children, specifically those diagnosed with ASD. The results of this study showed that age and gender specific normal ranges of isotopic composition must be established to effectively use isotopic composition analysis in studying various diseases including ASD.
摘要：
为了更好地了解锌和铜的调节及其在各种生化途径中的参与，因为它与自闭症谱系障碍（ASD）有关，在健康儿童和北美ASD儿童中评估了血清锌和铜的同位素组成.与健康对照和ASD儿童相比，血清锌或铜的同位素组成没有显着差异。然而,与先前发表的健康成人铜同位素组成相比，发现男孩的血清铜同位素组成富含65Cu。此外，在男孩和女孩身上，血清锌的平均同位素组成比以前发表的健康成人同位素锌组成重。男孩血清中的总锌浓度与血清中的锌同位素组成之间也存在负相关。最后,铜同位素组成较重的儿童的锌同位素组成也表现出高度的变异性。虽然许多研究已经测量了成人血清锌和铜的同位素组成，这是测量儿童血清铜和锌同位素组成的首批研究之一，特别是那些被诊断为ASD的人。这项研究的结果表明，必须建立年龄和性别特定的同位素组成正常范围，才能有效地使用同位素组成分析来研究包括ASD在内的各种疾病。
