Abstract：
Nanosized fluorescent carbon dots (Cdots) have gained a lot of attention in the recent years because of their superior properties, such as good biocompatibility, low toxicity, excellent chemical stability, resistance to photobleaching, and ease of chemical modification. Cdots are promising candidates for considerable applications in various fields: sensors, bioimaging, and drug delivery. Specifically, nitrogen-doped Cdots have attracted a huge interest because of their applicability in bioimaging and drug delivery. Conventional methods for the synthesis of Cdots have drawbacks, such as the use of organic solvents, the presence of side products, and the time required for synthesis. Keeping all these points in mind, herein, we report green methodology for the synthesis of water-soluble, blue-emitting, nitrogen-doped multifunctional Cdots under microwave irradiation within 3 min. The Cdots were prepared using citric acid and arginine as source materials and were characterized using various physicochemical techniques. A pH-responsive drug delivery system was then designed using anticancer drug doxorubicin and the synthesized Cdots. The biocompatibility of synthesized Cdots was analyzed against L929 normal cell line. The Cdots-DOX conjugates exhibited efficient anticancer activity against HeLa cells and also acted as excellent bioimaging agents.
摘要：
纳米荧光碳点(Cdots)由于其优越的性能,近年来受到了广泛的关注,如良好的生物相容性，低毒性,优异的化学稳定性，耐光漂白，和易于化学改性。Cdots是在各个领域应用的有希望的候选人：传感器，生物成像,和药物输送。具体来说,氮掺杂的Cdot由于其在生物成像和药物递送中的适用性而引起了极大的兴趣。用于合成Cdots的常规方法具有缺点,例如使用有机溶剂，副产品的存在，和合成所需的时间。记住所有这些要点，在这里，我们报道了合成水溶性的绿色方法，发蓝光,氮掺杂多功能Cdots在微波辐射下3分钟。使用柠檬酸和精氨酸作为原料制备Cdot，并使用各种物理化学技术进行表征。然后使用抗癌药物阿霉素和合成的Cdot设计pH响应性药物递送系统。针对L929正常细胞系分析合成的Cdot的生物相容性。Cdots-DOX缀合物对HeLa细胞表现出有效的抗癌活性，并且还用作出色的生物成像剂。
