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Abstract：
Neuroblastoma is a childhood neurological tumor which affects hundreds of thousands of children worldwide, and information about its prognosis can be pivotal for patients, their families, and clinicians. One of the main goals in the related bioinformatics analyses is to provide stable genetic signatures able to include genes whose expression levels can be effective to predict the prognosis of the patients. In this study, we collected the prognostic signatures for neuroblastoma published in the biomedical literature, and noticed that the most frequent genes present among them were three: AHCY, DPYLS3, and NME1. We therefore investigated the prognostic power of these three genes by performing a survival analysis and a binary classification on multiple gene expression datasets of different groups of patients diagnosed with neuroblastoma. Finally, we discussed the main studies in the literature associating these three genes with neuroblastoma. Our results, in each of these three steps of validation, confirm the prognostic capability of AHCY, DPYLS3, and NME1, and highlight their key role in neuroblastoma prognosis. Our results can have an impact on neuroblastoma genetics research: biologists and medical researchers can pay more attention to the regulation and expression of these three genes in patients having neuroblastoma, and therefore can develop better cures and treatments which can save patients\' lives.
摘要：
神经母细胞瘤是一种儿童神经系统肿瘤，影响全世界成千上万的儿童，关于其预后的信息对患者来说是至关重要的，他们的家人,和临床医生。相关生物信息学分析的主要目标之一是提供能够包括其表达水平可以有效预测患者预后的基因的稳定遗传特征。在这项研究中,我们收集了生物医学文献中发表的神经母细胞瘤的预后特征，并注意到其中最常见的基因是三个：AHCY，DPYLS3和NME1。因此，我们通过对诊断为神经母细胞瘤的不同组患者的多个基因表达数据集进行生存分析和二元分类来研究这三个基因的预后能力。最后,我们讨论了这三个基因与神经母细胞瘤相关的文献中的主要研究。我们的结果,在这三个验证步骤中，确认AHCY的预后能力，DPYLS3和NME1，并强调它们在神经母细胞瘤预后中的关键作用。我们的结果可以对神经母细胞瘤遗传学研究产生影响：生物学家和医学研究人员可以更加关注这三个基因在神经母细胞瘤患者中的调控和表达，因此，可以开发出更好的治疗和治疗方法，可以挽救病人的生命。
