PDF(Pubmed)
Abstract：
The pathogenic Escherichia coli can be parsed into specific variants (pathovars) depending on their phenotypic behavior and/or expression of specific virulence factors. These pathogens are built around chromosomally-encoded core attributes and through acquisition of specific virulence genes that direct their interaction with the host. Engagement of E. coli pathovars with CEACAMs is determined both by core elements common to all E. coli as well as extrachromosomally-encoded pathovar-specific virulence traits, which target amino terminal immunoglobulin variable-like (IgV) regions of CEACAMs. Emerging data suggests that engagement of CEACAMs does not unilaterally benefit the pathogen and that these interactions may also provide an avenue for pathogen elimination.
摘要：
致病性大肠杆菌可以根据它们的表型行为和/或特定毒力因子的表达被解析为特定变体(病态变种)。这些病原体围绕染色体编码的核心属性建立，并通过获取指导其与宿主相互作用的特定毒力基因。大肠杆菌病态与CEACAM的接合取决于所有大肠杆菌共有的核心元件以及染色体外编码的病态特异性毒力性状，新出现的数据表明，CEACAM的参与不会单方面使病原体受益，并且这些相互作用也可能为病原体消除提供途径。
