PDF(Pubmed)
Abstract：
UNASSIGNED: Quantification of retinal xanthophyll carotenoids in eyes with and without age-related macular degeneration (AMD) via macular pigment optical volume (MPOV), a metric for xanthophyll abundance from dual wavelength autofluorescence, plus correlations to plasma levels, could clarify the role of lutein (L) and zeaxanthin (Z) in health, AMD progression, and supplementation strategies.
UNASSIGNED: Cross-sectional observational study (NCT04112667).
UNASSIGNED: Adults ≥ 60 years from a comprehensive ophthalmology clinic, with healthy maculas or maculas meeting fundus criteria for early or intermediate AMD.
UNASSIGNED: Macular health and supplement use was assessed by the Age-related Eye Disease Study (AREDS) 9-step scale and self-report, respectively. Macular pigment optical volume was measured from dual wavelength autofluorescence emissions (Spectralis, Heidelberg Engineering). Non-fasting blood draws were assayed for L and Z using high-performance liquid chromatography. Associations among plasma xanthophylls and MPOV were assessed adjusting for age.
UNASSIGNED: Age-related macular degeneration presence and severity, MPOV in fovea-centered regions of radius 2.0° and 9.0°; plasma L and Z (μM/ml).
UNASSIGNED: Of 809 eyes from 434 persons (89% aged 60-79, 61% female), 53.3% eyes were normal, 28.2% early AMD, and 18.5% intermediate AMD. Macular pigment optical volume 2° and 9° were similar in phakic and pseudophakic eyes, which were combined for analysis. Macular pigment optical volume 2° and 9° and plasma L and Z were higher in early AMD than normal and higher still in intermediate AMD (P < 0.0001). For all participants, higher plasma L was correlated with higher MPOV 2° (Spearman correlation coefficient [Rs] = 0.49; P < 0.0001). These correlations were significant (P < 0.0001) but lower in normal (Rs = 0.37) than early and intermediate AMD (Rs = 0.52 and 0.51, respectively). Results were similar for MPOV 9°. Plasma Z, MPOV 2°, and MPOV 9° followed this same pattern of associations. Associations were not affected by supplement use or smoking status.
UNASSIGNED: A moderate positive correlation of MPOV with plasma L and Z comports with regulated xanthophyll bioavailability and a hypothesized role for xanthophyll transfer in soft drusen biology. An assumption that xanthophylls are low in AMD retina underlies supplementation strategies to reduce progression risk, which our data do not support. Whether higher xanthophyll levels in AMD are due to supplement use cannot be determined in this study.
UNASSIGNED: Cross-sectional observational study (NCT04112667).
UNASSIGNED: Adults ≥ 60 years from a comprehensive ophthalmology clinic, with healthy maculas or maculas meeting fundus criteria for early or intermediate AMD.
UNASSIGNED: Macular health and supplement use was assessed by the Age-related Eye Disease Study (AREDS) 9-step scale and self-report, respectively. Macular pigment optical volume was measured from dual wavelength autofluorescence emissions (Spectralis, Heidelberg Engineering). Non-fasting blood draws were assayed for L and Z using high-performance liquid chromatography. Associations among plasma xanthophylls and MPOV were assessed adjusting for age.
UNASSIGNED: Age-related macular degeneration presence and severity, MPOV in fovea-centered regions of radius 2.0° and 9.0°; plasma L and Z (μM/ml).
UNASSIGNED: Of 809 eyes from 434 persons (89% aged 60-79, 61% female), 53.3% eyes were normal, 28.2% early AMD, and 18.5% intermediate AMD. Macular pigment optical volume 2° and 9° were similar in phakic and pseudophakic eyes, which were combined for analysis. Macular pigment optical volume 2° and 9° and plasma L and Z were higher in early AMD than normal and higher still in intermediate AMD (P < 0.0001). For all participants, higher plasma L was correlated with higher MPOV 2° (Spearman correlation coefficient [Rs] = 0.49; P < 0.0001). These correlations were significant (P < 0.0001) but lower in normal (Rs = 0.37) than early and intermediate AMD (Rs = 0.52 and 0.51, respectively). Results were similar for MPOV 9°. Plasma Z, MPOV 2°, and MPOV 9° followed this same pattern of associations. Associations were not affected by supplement use or smoking status.
UNASSIGNED: A moderate positive correlation of MPOV with plasma L and Z comports with regulated xanthophyll bioavailability and a hypothesized role for xanthophyll transfer in soft drusen biology. An assumption that xanthophylls are low in AMD retina underlies supplementation strategies to reduce progression risk, which our data do not support. Whether higher xanthophyll levels in AMD are due to supplement use cannot be determined in this study.
摘要：
未经证实：通过黄斑色素光学体积（MPOV）对有和没有年龄相关性黄斑变性（AMD）的眼睛中的视网膜叶黄素类胡萝卜素进行定量，来自双波长自发荧光的叶黄素丰度度量，加上与血浆水平的相关性，可以阐明叶黄素（L）和玉米黄质（Z）在健康中的作用，AMD进展，补充策略。
UNASSIGNED：横断面观察性研究(NCT04112667)。
UNASSIGNED：来自综合眼科诊所的≥60岁成年人，健康黄斑或黄斑符合早期或中期AMD的眼底标准。
未经评估：通过年龄相关性眼病研究（AREDS）9步量表和自我报告评估了黄斑健康和补充剂的使用，分别。从双波长自发荧光发射测量黄斑色素光学体积(光谱，海德堡工程公司）。使用高效液相色谱法测定非空腹抽血的L和Z。根据年龄对血浆叶黄素和MPOV之间的关联进行评估。
未经证实：年龄相关性黄斑变性的存在和严重程度，半径为2.0°和9.0°的中央凹区域中的MPOV；血浆L和Z（μM/ml）。
未经评估：在434人中的809只眼睛中（89％年龄在60-79岁之间，61％为女性），53.3%的眼睛是正常的,28.2%早期AMD,和18.5%的中间AMD。有晶状体和假晶状体眼的黄斑色素光学体积2°和9°相似，结合起来进行分析。早期AMD的黄斑色素光学体积2°和9°以及血浆L和Z高于正常水平，而中度AMD则更高（P<0.0001）。对于所有参与者，较高的血浆L与较高的MPOV2°相关(Spearman相关系数[Rs]=0.49;P<0.0001).这些相关性是显着的（P<0.0001），但在正常（Rs=0.37）中低于早期和中期AMD（Rs分别为0.52和0.51）。MPOV9°的结果相似。血浆Z,MPOV2°,MPOV9°遵循相同的关联模式。协会不受补充剂使用或吸烟状况的影响。
UNASSIGNED：MPOV与血浆L和Z的中度正相关，具有调节的叶黄素生物利用度和假设的叶黄素转移在软玻璃疣生物学中的作用。假设AMD视网膜中的叶黄素含量较低是降低进展风险的补充策略的基础。我们的数据不支持。在本研究中无法确定AMD中较高的叶黄素水平是否是由于补充使用所致。
UNASSIGNED：横断面观察性研究(NCT04112667)。
UNASSIGNED：来自综合眼科诊所的≥60岁成年人，健康黄斑或黄斑符合早期或中期AMD的眼底标准。
未经评估：通过年龄相关性眼病研究（AREDS）9步量表和自我报告评估了黄斑健康和补充剂的使用，分别。从双波长自发荧光发射测量黄斑色素光学体积(光谱，海德堡工程公司）。使用高效液相色谱法测定非空腹抽血的L和Z。根据年龄对血浆叶黄素和MPOV之间的关联进行评估。
未经证实：年龄相关性黄斑变性的存在和严重程度，半径为2.0°和9.0°的中央凹区域中的MPOV；血浆L和Z（μM/ml）。
未经评估：在434人中的809只眼睛中（89％年龄在60-79岁之间，61％为女性），53.3%的眼睛是正常的,28.2%早期AMD,和18.5%的中间AMD。有晶状体和假晶状体眼的黄斑色素光学体积2°和9°相似，结合起来进行分析。早期AMD的黄斑色素光学体积2°和9°以及血浆L和Z高于正常水平，而中度AMD则更高（P<0.0001）。对于所有参与者，较高的血浆L与较高的MPOV2°相关(Spearman相关系数[Rs]=0.49;P<0.0001).这些相关性是显着的（P<0.0001），但在正常（Rs=0.37）中低于早期和中期AMD（Rs分别为0.52和0.51）。MPOV9°的结果相似。血浆Z,MPOV2°,MPOV9°遵循相同的关联模式。协会不受补充剂使用或吸烟状况的影响。
UNASSIGNED：MPOV与血浆L和Z的中度正相关，具有调节的叶黄素生物利用度和假设的叶黄素转移在软玻璃疣生物学中的作用。假设AMD视网膜中的叶黄素含量较低是降低进展风险的补充策略的基础。我们的数据不支持。在本研究中无法确定AMD中较高的叶黄素水平是否是由于补充使用所致。
