Eight healthy participants (two females, six males, mean age 69.3 ± 1.2 years, body mass index 23.5 ± 0.8 kg/m2 ) were each studied on four occasions when they received an intraduodenal infusion of either (i) 0.9% saline or (ii) glucose delivered at a rate of 3 kcal/min both with, and without, an intragastric balloon with the pressure set to 8 mmHg above the intragastric minimum distending pressure.
Following intraduodenal saline or glucose infusion, there was no difference in plasma GLP-1 with or without gastric distension (P = 1.00 for both saline and glucose infusions). There was also no difference in plasma GIP with or without gastric distension (P = 1.00 for saline infusion and P = .99 for glucose infusion).
Gastric distension, either alone or during small intestinal glucose exposure, does not stimulate incretin hormone secretion significantly in healthy humans.
方法:8名健康参与者(2名女性,6男,平均年龄69.3±1.2岁,和体重指数23.5±0.8kg/m2)分别在四次接受十二指肠内输注(i)0.9%盐水或(ii)以3kcal/min的速率输送的葡萄糖时进行了研究,没有,压力设定为高于胃内最小膨胀压力8mmHg的胃内气球。
结果:十二指肠内盐水或葡萄糖输注后,有或没有胃扩张的血浆GLP-1无差异(生理盐水和葡萄糖输注P=1.00).有或没有胃扩张的血浆GIP也没有差异(生理盐水输注P=1.00,葡萄糖输注P=0.99)。
结论:我们得出结论,单独或在小肠葡萄糖暴露期间,在健康人中不显著刺激肠促胰岛素激素分泌。本文受版权保护。保留所有权利。