PDF(Pubmed)
Abstract：
To evaluate the effect of gastric distension, induced using a gastric \'barostat\', on the secretion of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) in the presence and absence of small intestinal nutrients in healthy individuals.
Eight healthy participants (two females, six males, mean age 69.3 ± 1.2 years, body mass index 23.5 ± 0.8 kg/m2 ) were each studied on four occasions when they received an intraduodenal infusion of either (i) 0.9% saline or (ii) glucose delivered at a rate of 3 kcal/min both with, and without, an intragastric balloon with the pressure set to 8 mmHg above the intragastric minimum distending pressure.
Following intraduodenal saline or glucose infusion, there was no difference in plasma GLP-1 with or without gastric distension (P = 1.00 for both saline and glucose infusions). There was also no difference in plasma GIP with or without gastric distension (P = 1.00 for saline infusion and P = .99 for glucose infusion).
Gastric distension, either alone or during small intestinal glucose exposure, does not stimulate incretin hormone secretion significantly in healthy humans.
Eight healthy participants (two females, six males, mean age 69.3 ± 1.2 years, body mass index 23.5 ± 0.8 kg/m2 ) were each studied on four occasions when they received an intraduodenal infusion of either (i) 0.9% saline or (ii) glucose delivered at a rate of 3 kcal/min both with, and without, an intragastric balloon with the pressure set to 8 mmHg above the intragastric minimum distending pressure.
Following intraduodenal saline or glucose infusion, there was no difference in plasma GLP-1 with or without gastric distension (P = 1.00 for both saline and glucose infusions). There was also no difference in plasma GIP with or without gastric distension (P = 1.00 for saline infusion and P = .99 for glucose infusion).
Gastric distension, either alone or during small intestinal glucose exposure, does not stimulate incretin hormone secretion significantly in healthy humans.
摘要：
目的：使用胃内气球作为减肥程序的兴趣日益增加，然而,潜在的机制仍不清楚。在啮齿动物中，胃胀最近被证明可以刺激肠促胰岛素激素胰高血糖素样肽-1（GLP-1）的分泌，但是胃胀对GLP-1和其他肠促胰岛素激素的影响，葡萄糖依赖性促胰岛素多肽（GIP），在人类中是未知的。我们做了一个随机的,控制,交叉研究，以评估胃胀的影响，在健康个体中使用胃“barostat”对肠促胰岛素激素进行诱导。
方法：8名健康参与者（2名女性，6男,平均年龄69.3±1.2岁，和体重指数23.5±0.8kg/m2）分别在四次接受十二指肠内输注（i）0.9％盐水或（ii）以3kcal/min的速率输送的葡萄糖时进行了研究，没有，压力设定为高于胃内最小膨胀压力8mmHg的胃内气球。
结果：十二指肠内盐水或葡萄糖输注后，有或没有胃扩张的血浆GLP-1无差异(生理盐水和葡萄糖输注P=1.00).有或没有胃扩张的血浆GIP也没有差异（生理盐水输注P=1.00，葡萄糖输注P=0.99）。
结论：我们得出结论，单独或在小肠葡萄糖暴露期间，在健康人中不显著刺激肠促胰岛素激素分泌。本文受版权保护。保留所有权利。
方法：8名健康参与者（2名女性，6男,平均年龄69.3±1.2岁，和体重指数23.5±0.8kg/m2）分别在四次接受十二指肠内输注（i）0.9％盐水或（ii）以3kcal/min的速率输送的葡萄糖时进行了研究，没有，压力设定为高于胃内最小膨胀压力8mmHg的胃内气球。
结果：十二指肠内盐水或葡萄糖输注后，有或没有胃扩张的血浆GLP-1无差异(生理盐水和葡萄糖输注P=1.00).有或没有胃扩张的血浆GIP也没有差异（生理盐水输注P=1.00，葡萄糖输注P=0.99）。
结论：我们得出结论，单独或在小肠葡萄糖暴露期间，在健康人中不显著刺激肠促胰岛素激素分泌。本文受版权保护。保留所有权利。
