Abstract：
OBJECTIVE: Gastric precancerous conditions such as atrophic gastritis (AG) and intestinal metaplasia (IM) are considered independent risk factors for gastric cancer (GC). The suitable endoscopic monitoring interval is unclear when we attempt to prevent GC development. This study investigated the appropriate monitoring interval for AG/IM patients.
METHODS: Totally, 957 AG/IM patients who satisfied the criteria for evaluation between 2010 and 2020 were included in the study. Univariate and multivariate analyses were used to determine the risk factors for progression to high-grade intraepithelial neoplasia (HGIN)/GC in AG/IM patients, and to determine an appropriate endoscopic monitoring scheme.
RESULTS: During follow-up, 28 AG/IM patients developed gastric neoplasia lesions including gastric low-grade intraepithelial neoplasia (LGIN) (0.7%), HGIN (0.9%), and GC (1.3%). Multivariate analysis identified H. pylori infection (P=0.022) and extensive AG/IM lesions (P=0.002) as risk factors for HGIN/GC progression (P=0.025).
CONCLUSIONS: In our study, HGIN/GC was present in 2.2% of AG/IM patients. In AG/IM patients with extensive lesions, a 1-2-year surveillance interval is recommended for early detection of HIGN/GC in AG/IM patients with extensive lesions.
METHODS: Totally, 957 AG/IM patients who satisfied the criteria for evaluation between 2010 and 2020 were included in the study. Univariate and multivariate analyses were used to determine the risk factors for progression to high-grade intraepithelial neoplasia (HGIN)/GC in AG/IM patients, and to determine an appropriate endoscopic monitoring scheme.
RESULTS: During follow-up, 28 AG/IM patients developed gastric neoplasia lesions including gastric low-grade intraepithelial neoplasia (LGIN) (0.7%), HGIN (0.9%), and GC (1.3%). Multivariate analysis identified H. pylori infection (P=0.022) and extensive AG/IM lesions (P=0.002) as risk factors for HGIN/GC progression (P=0.025).
CONCLUSIONS: In our study, HGIN/GC was present in 2.2% of AG/IM patients. In AG/IM patients with extensive lesions, a 1-2-year surveillance interval is recommended for early detection of HIGN/GC in AG/IM patients with extensive lesions.
摘要：
目的：胃癌前病变如萎缩性胃炎(AG)、肠上皮化生(IM)是胃癌(GC)的独立危险因素。当我们试图防止GC发展时，合适的内窥镜监测间隔尚不清楚。这项研究调查了AG/IM患者的适当监测间隔。
方法：完全，在2010年至2020年间满足评估标准的957名AG/IM患者被纳入研究。单变量和多变量分析用于确定AG/IM患者进展为高级别上皮内瘤变（HGIN）/GC的危险因素，并确定合适的内镜监测方案。
结果：随访期间，28例AG/IM患者出现胃瘤变病变，包括胃低级别上皮内瘤变（LGIN）（0.7%），HGIN（0.9%），和GC（1.3%）。多因素分析确定幽门螺杆菌感染（P=0.022）和广泛的AG/IM病变（P=0.002）是HGIN/GC进展的危险因素（P=0.025）。
结论：在我们的研究中，2.2%的AG/IM患者存在HGIN/GC。在具有广泛病变的AG/IM患者中，建议对广泛病变的AG/IM患者进行1-2年的监测,以便早期发现HIGN/GC.
方法：完全，在2010年至2020年间满足评估标准的957名AG/IM患者被纳入研究。单变量和多变量分析用于确定AG/IM患者进展为高级别上皮内瘤变（HGIN）/GC的危险因素，并确定合适的内镜监测方案。
结果：随访期间，28例AG/IM患者出现胃瘤变病变，包括胃低级别上皮内瘤变（LGIN）（0.7%），HGIN（0.9%），和GC（1.3%）。多因素分析确定幽门螺杆菌感染（P=0.022）和广泛的AG/IM病变（P=0.002）是HGIN/GC进展的危险因素（P=0.025）。
结论：在我们的研究中，2.2%的AG/IM患者存在HGIN/GC。在具有广泛病变的AG/IM患者中，建议对广泛病变的AG/IM患者进行1-2年的监测,以便早期发现HIGN/GC.
