Abstract：
Studies have demonstrated the detrimental effects of overt hyperthyroidism on sexual functioning.Here,we comprehensively reviewed the studies that focused on the association between overt hyperthyroidism and erectile dysfunction (ED).After the systematic searching for relevant studies,we find that overt hyperthyroidism is significantly associated with the high risk of ED.The prevalence of ED in patients with hyperthyroidism ranges from 3.05% to 85%,while that in general population is 2.16% to 33.8%.A study reported that the erectile functioning of the hyperthyroidism patients was improved (International Index of Erectile Function:22.1±6.9 vs. 25.2±5.1) after the achievement of euthyroidism.The underlying mechanism of the increase in the risk of ED by overt hyperthyroidism might be correlated to the dysfunction of hypothalamus-pituitary-thyroid axis,dysregulation of sex hormones,abnormal expression of thyroid hormone receptors,and psychiatric or psychological disturbances (e.g.,depression,anxiety,and irritability).Since limited clinical trials have been conducted,additional well-designed cohorts with sizable samples are warranted to elucidate the evidence and mechanism of hyperthyroidism predisposing to ED.The present review indicates that overt hyperthyroidism and the risk of ED are associated,which reminds the clinicians should assess the thyroid stimulating hormone in hyperthyroidism patients presenting with ED,especially in those without positive conventional laboratory findings for causing ED.
摘要：
研究已经证明了明显的甲状腺功能亢进对性功能的有害影响。这里,我们全面回顾了关注明显的甲状腺功能亢进与勃起功能障碍(ED)之间关联的研究.在系统搜索相关研究后，我们发现明显的甲状腺功能亢进与ED的高风险显著相关.甲状腺功能亢进患者的ED患病率为3.05%至85%,而在一般人口中，这一比例为2.16%至33.8%。一项研究报告说，甲状腺功能亢进患者的勃起功能得到改善（国际勃起功能指数：22.1±6.9vs.25.2±5.1）在实现甲状腺功能正常后。明显的甲状腺功能亢进增加ED风险的潜在机制可能与下丘脑-垂体-甲状腺轴功能障碍有关。性激素失调,甲状腺激素受体异常表达，和精神或心理障碍(例如，抑郁症,焦虑,和烦躁)。由于已经进行了有限的临床试验，我们需要更多设计良好的样本队列,以阐明甲状腺功能亢进诱发ED的证据和机制.本综述表明，明显的甲状腺功能亢进与ED的风险相关，提醒临床医生应评估甲状腺功能亢进患者的促甲状腺激素，尤其是那些没有引起ED的常规实验室检查结果的人。
