Abstract：
OBJECTIVE: Type 2 diabetes is associated with deficits in cognition and brain health. Individuals with at least 1 risk factor for diabetes (i.e. obesity, prediabetes) already experience some neurocognitive impairment and are at risk for further decline. One way to combat these deficits is through exercise, but it is unknown whether resistance exercise can improve these functions in this at-risk group.
METHODS: This study was a pilot randomized controlled trial. Participants were 60 to 80 years of age and had prediabetes (fasting capillary glucose 6.1 to 6.9 mmol/L) and/or were living with overweight or obesity (body mass index ≥25 kg/m2). Participants completed resistance training or balance and stretching exercises (control) thrice weekly for 6 months. Neuropsychological tests were used to assess cognitive ability, whereas functional magnetic resonance imaging was used to examine brain activation patterns.
RESULTS: Resistance training led to improvements in task-switching, attention, and conflict resolution, as well as improved patterns of brain activation that may mimic healthy older adults.
CONCLUSIONS: Resistance exercise may serve as an effective behavioural strategy to improve neurocognition in older adults at risk for type 2 diabetes. A large-scale powered trial is needed to further explore these findings.
METHODS: This study was a pilot randomized controlled trial. Participants were 60 to 80 years of age and had prediabetes (fasting capillary glucose 6.1 to 6.9 mmol/L) and/or were living with overweight or obesity (body mass index ≥25 kg/m2). Participants completed resistance training or balance and stretching exercises (control) thrice weekly for 6 months. Neuropsychological tests were used to assess cognitive ability, whereas functional magnetic resonance imaging was used to examine brain activation patterns.
RESULTS: Resistance training led to improvements in task-switching, attention, and conflict resolution, as well as improved patterns of brain activation that may mimic healthy older adults.
CONCLUSIONS: Resistance exercise may serve as an effective behavioural strategy to improve neurocognition in older adults at risk for type 2 diabetes. A large-scale powered trial is needed to further explore these findings.
摘要：
目的：2型糖尿病与认知和大脑健康的缺陷有关。具有至少1个糖尿病危险因素的个体(即肥胖，糖尿病前期）已经经历了一些神经认知障碍，并且有进一步下降的风险。对抗这些缺陷的一种方法是通过锻炼，但目前尚不清楚抗阻运动是否能改善这个高危人群的这些功能。
方法：本研究是一项随机对照试验。参与者年龄为60至80岁，患有糖尿病前期（空腹毛细血管葡萄糖6.1至6.9mmol/L）和/或超重或肥胖（体重指数≥25）。参与者每周三次完成阻力训练或平衡和伸展运动（对照），持续6个月。神经心理学测试用于评估认知能力，而功能磁共振成像用于检查大脑激活模式。
结果：阻力训练导致任务切换的改善，关注和解决冲突，以及改善的大脑激活模式，可以模仿健康的老年人。
结论：抗阻运动可以作为一种有效的行为策略来改善有2型糖尿病风险的老年人的神经认知。需要进行大规模的有力试验来进一步探索这些发现。
方法：本研究是一项随机对照试验。
结果：阻力训练导致任务切换的改善，
结论：抗阻运动可以作为一种有效的行为策略来改善有2型糖尿病风险的老年人的神经认知。
