Abstract：
The interleukin 6 (IL-6) family of cytokines is defined by the usage of gp130, a common β-receptor signaling subunit, which promotes a variety of signals. They induce many biological functions on many cell types, including immune and inflammatory cells. They also exhibit hormone-like features, which are involved in homeostatic processes. Signal transducer and activator of transcription 3 (STAT3) is a significant signaling molecule fundamental in regulating IL-6/gp130 and is highly implicated in pathological conditions; therefore, STAT3 activation is tightly regulated through various mechanisms and at multiple levels. There is a large amount of information about STAT3-interacting proteins, which positively or negatively regulate STAT3 activity. This review is focused on IL-6-mediated signal transduction and the introduction of novel STAT3-binding partners. The review will help develop new strategies for clinically controlling the functions of IL-6/STAT3.
摘要：
细胞因子的白细胞介素6（IL-6）家族由gp130（一种常见的β受体信号亚基）的使用定义。这促进了各种信号。它们在许多细胞类型上诱导许多生物学功能，包括免疫和炎症细胞。它们还表现出激素样的特征，参与稳态过程。信号转导和转录激活因子3（STAT3）是调节IL-6/gp130的重要信号分子，与病理状况密切相关；因此，STAT3激活通过各种机制和多个水平受到严格调节。有大量关于STAT3相互作用蛋白的信息，正或负调节STAT3活性。这篇综述集中在IL-6介导的信号转导和新型STAT3结合伴侣的引入。该综述将有助于开发临床控制IL-6/STAT3功能的新策略。
