Abstract：
Atypical spindle cell/pleomorphic lipomatous tumour (ASPLT) is an infrequently appreciated benign lipomatous neoplasm newly accepted into the most recent WHO classification of soft tissue tumours.
Our cytopathology files were searched for examples of ASPLT and spindle cell/pleomorphic lipoma (SCPL) having histopathological verification. Conventional fine needle aspiration (FNA) biopsy smears were performed using standard techniques.
Eleven patients including three cases of ASPLT and eight of SCPL (M:F = 4.5:1; age range: 39-97 years, mean age = 60 years) met the inclusion criteria. FNA biopsy sites included extremity (5, 45%), trunk (3, 27%), and head/neck (3, 27%). All aspirates were from primary neoplasms. FNA diagnoses of ASPLT cases were spindle cell lipomatous neoplasm, fibrotic low-grade SC neoplasm, and myxoid lipomatous neoplasm. Eight SCPL cases were diagnosed as spindle cell neoplasm (3), spindle cell lipoma (SCL) (1), pleomorphic lipoma (1), suspicious for SCL (1), benign adipose tissue (1), and benign spindle cells and connective tissue (1). Ancillary testing in two ASPLT cases showed positive CD34 and negative MDM2 immunostain in one, and negative FISH results for MDM2 and DDIT3 in another.
ASPLT is a novel lipomatous neoplasm simulating primarily SCPL and atypical lipoma/well-differentiated liposarcoma. Diligent cytomorphological observation, clinical information, and ancillary testing may allow for its specific recognition using FNA biopsy.
Our cytopathology files were searched for examples of ASPLT and spindle cell/pleomorphic lipoma (SCPL) having histopathological verification. Conventional fine needle aspiration (FNA) biopsy smears were performed using standard techniques.
Eleven patients including three cases of ASPLT and eight of SCPL (M:F = 4.5:1; age range: 39-97 years, mean age = 60 years) met the inclusion criteria. FNA biopsy sites included extremity (5, 45%), trunk (3, 27%), and head/neck (3, 27%). All aspirates were from primary neoplasms. FNA diagnoses of ASPLT cases were spindle cell lipomatous neoplasm, fibrotic low-grade SC neoplasm, and myxoid lipomatous neoplasm. Eight SCPL cases were diagnosed as spindle cell neoplasm (3), spindle cell lipoma (SCL) (1), pleomorphic lipoma (1), suspicious for SCL (1), benign adipose tissue (1), and benign spindle cells and connective tissue (1). Ancillary testing in two ASPLT cases showed positive CD34 and negative MDM2 immunostain in one, and negative FISH results for MDM2 and DDIT3 in another.
ASPLT is a novel lipomatous neoplasm simulating primarily SCPL and atypical lipoma/well-differentiated liposarcoma. Diligent cytomorphological observation, clinical information, and ancillary testing may allow for its specific recognition using FNA biopsy.
摘要：
背景：非典型梭形细胞/多形性脂肪瘤（ASPLT）是一种少见的良性脂肪瘤，新近被WHO最新的软组织肿瘤分类所接受。
方法：在我们的细胞病理学文件中搜索了具有组织病理学验证的ASPLT和梭形细胞/多形性脂肪瘤（SCPL）的例子。使用标准技术进行常规FNA活检涂片。
结果：11例患者，其中ASPLT3例，SCPL8例[M：F=4.5：1；年龄范围：39至97岁，平均年龄=60岁]符合纳入标准。FNA活检部位包括四肢（5，45%），树干（3，27%），和头/颈部（3，27％）。所有抽吸物来自原发性肿瘤。ASPLT病例的FNA诊断为梭形细胞（SC）脂肪瘤，纤维化低级别SC肿瘤，和粘液样脂肪瘤。8例SCPL诊断为梭形细胞肿瘤（3例），梭形细胞脂肪瘤（SCL）（1），PL(1),可疑SCL（1），良性脂肪组织(1)，和良性梭形细胞和结缔组织（1）。2例ASPLT病例的辅助测试显示，1例CD34阳性和MDM2免疫染色阴性，另一例MDM2和DDIT3的FISH结果阴性。
结论：ASPLT是一种新型脂肪瘤，主要模拟SCPL和非典型脂肪瘤/高分化脂肪肉瘤。细致的细胞形态学观察,临床信息，和辅助测试可以允许其特定的识别使用FNA活检。
方法：在我们的细胞病理学文件中搜索了具有组织病理学验证的ASPLT和梭形细胞/多形性脂肪瘤（SCPL）的例子。使用标准技术进行常规FNA活检涂片。
结果：11例患者，其中ASPLT3例，SCPL8例[M：F=4.5：1；年龄范围：39至97岁，平均年龄=60岁]符合纳入标准。FNA活检部位包括四肢（5，45%），树干（3，27%），和头/颈部（3，27％）。所有抽吸物来自原发性肿瘤。ASPLT病例的FNA诊断为梭形细胞（SC）脂肪瘤，纤维化低级别SC肿瘤，和粘液样脂肪瘤。8例SCPL诊断为梭形细胞肿瘤（3例），梭形细胞脂肪瘤（SCL）（1），PL(1),可疑SCL（1），良性脂肪组织(1)，和良性梭形细胞和结缔组织（1）。2例ASPLT病例的辅助测试显示，1例CD34阳性和MDM2免疫染色阴性，另一例MDM2和DDIT3的FISH结果阴性。
结论：ASPLT是一种新型脂肪瘤，主要模拟SCPL和非典型脂肪瘤/高分化脂肪肉瘤。细致的细胞形态学观察,临床信息，和辅助测试可以允许其特定的识别使用FNA活检。
