Abstract：
The range of an ablation zone (AZ) plays a crucial role in the treatment effect of microwave ablation (MWA). The aim of this study was to analyze the factors influencing the AZ range.
Fourteen factors in four areas were included: patient-related factors (sex, age), disease-related factors (tumor location, liver cirrhosis), serological factors (ALT, AST, total protein, albumin, total bilirubin, direct bilirubin, and platelets), and MWA parameters (ablation time, power, and needle type). Multiple sequence MRI was used to delineate AZ by three radiologists using 3D Slicer. MATLAB was used to calculate the AZ length, width, and area of the largest section. Linear regression analysis was used to analyze influencing factors. Moreover, a subgroup analysis was conducted for patients with viral hepatitis.
220 patients with 290 tumors were included between 2010-2021. In addition to MWA parameters, cirrhosis and tumor location were significant factors that influenced AZ (p < 0.001). The standardized coefficient (beta) of cirrhosis (cirrhosis vs. non-cirrhosis) was positive, which meant cirrhosis would lead to a decrease in AZ range. The beta of tumor location (near the hepatic hilar zone, intermediate zone, and periphery zone) was negative, indicating that AZ range decreased as the tumor location approached the hepatic hilum. For viral hepatitis patients, Fibrosis 4 (FIB4) score was a significant factor influencing AZ (p < 0.001), and the beta was negative, indicating that AZ range decreased as FIB4 increased.
Liver cirrhosis, tumor location, and FIB4 affect the AZ range and should be considered when planning MWA parameters.
Fourteen factors in four areas were included: patient-related factors (sex, age), disease-related factors (tumor location, liver cirrhosis), serological factors (ALT, AST, total protein, albumin, total bilirubin, direct bilirubin, and platelets), and MWA parameters (ablation time, power, and needle type). Multiple sequence MRI was used to delineate AZ by three radiologists using 3D Slicer. MATLAB was used to calculate the AZ length, width, and area of the largest section. Linear regression analysis was used to analyze influencing factors. Moreover, a subgroup analysis was conducted for patients with viral hepatitis.
220 patients with 290 tumors were included between 2010-2021. In addition to MWA parameters, cirrhosis and tumor location were significant factors that influenced AZ (p < 0.001). The standardized coefficient (beta) of cirrhosis (cirrhosis vs. non-cirrhosis) was positive, which meant cirrhosis would lead to a decrease in AZ range. The beta of tumor location (near the hepatic hilar zone, intermediate zone, and periphery zone) was negative, indicating that AZ range decreased as the tumor location approached the hepatic hilum. For viral hepatitis patients, Fibrosis 4 (FIB4) score was a significant factor influencing AZ (p < 0.001), and the beta was negative, indicating that AZ range decreased as FIB4 increased.
Liver cirrhosis, tumor location, and FIB4 affect the AZ range and should be considered when planning MWA parameters.
摘要：
UNASSIGNED：消融区（AZ）的范围在微波消融（MWA）的治疗效果中起着至关重要的作用。本研究的目的是分析影响AZ范围的因素。
UNASSIGNED：包括四个方面的十四个因素：患者相关因素（性别，年龄),疾病相关因素(肿瘤位置，肝硬化），血清学因素（ALT，AST,总蛋白质，白蛋白,总胆红素,直接胆红素,和血小板），和MWA参数(消融时间，电源,和针头类型）。三位放射科医生使用3D切片器使用多序列MRI来描绘AZ。MATLAB用于计算AZ长度，宽度,和面积最大的部分。采用线性回归分析影响因素。此外，对病毒性肝炎患者进行了亚组分析.
UNASSIGNED：在2010-2021年间纳入了220例患者，其中290例肿瘤。除了MWA参数，肝硬化和肿瘤位置是影响AZ的重要因素（p<0.001）。肝硬化的标准化系数（β）（肝硬化与非肝硬化）呈阳性，这意味着肝硬化会导致AZ范围的降低。肿瘤位置的β（靠近肝门区，中间区,和外围区)为阴性，表明AZ范围随着肿瘤位置接近肝门而降低。对于病毒性肝炎患者，纤维化4(FIB4)评分是影响AZ的显著因素(p<0.001),贝塔是负的，表明AZ范围随着FIB4的增加而降低。
未经证实：肝硬化，肿瘤位置,和FIB4会影响AZ范围，在规划MWA参数时应予以考虑。
UNASSIGNED：包括四个方面的十四个因素：患者相关因素（性别，
UNASSIGNED：在2010-2021年间纳入了220例患者，其中290例肿瘤。
未经证实：肝硬化，
