A case of Avelumab response to multiple bone and lymph node metastases of plasmacytoid variant bladder cancer.

一例 Avelumab 对浆细胞样变异型膀胱癌的多发性骨和淋巴结转移的反应。

• 发表时间: Mar 2023
• 来源期刊: Urol Case Rep
• DOI: 10.1016/j.eucr.2023.102358
• PMID: 36852129
• 文章类型: Case Reports
• 作者列表: Kokura K,Watanabe J,Takuma T,Uketa S,Uemura Y,Uegaki M

关键词: Avelumab; Bladder cancer; CT, Computed tomography; HE, Hematoxylin and eosin; MRI, Magnetic Resonance Imaging; Plasmacytoid

Abstract

A 74-year-old man was diagnosed with bladder cancer and referred to our department. For definitive diagnosis, transurethral resection of the bladder tumor(TURBT) was performed. The pathological result showed plasmacytoid variant of urothelial carcinoma. Subsequently, robot-assisted radical cystectomy, lymph node dissection and ileal conduit was performed, but multiple bone metastases and periaortic lymph node metastases newly appeared 30 days later. Gemcitabine and cisplatin (GC) was started, and after 4 courses, the patient became Partial Response (PR), and was switched to Avelumab as maintenance therapy. After about 1 year of maintenance therapy, the patient is still in PR.

摘要

一名74岁的男子被诊断出患有膀胱癌，并转诊到我们部门。为了明确诊断，经尿道膀胱肿瘤切除术(TURBT).病理结果为尿路上皮癌浆细胞样变异型。随后，机器人辅助根治性膀胱切除术,进行淋巴结清扫和回肠导管，但30天后新出现多发骨转移和主动脉周围淋巴结转移。开始使用吉西他滨和顺铂（GC），在四门课程之后，患者出现部分缓解（PR），并改用Avelumab作为维持治疗。维持治疗1年后，患者仍处于公关状态。