Abstract：
Cancer is a risk factor for venous thromboembolism (VTE). We aimed to define sex-specific risk of preceding cancer in patients with a first-time VTE by conducting a nationwide Swedish registry-based study including 298 172 patients with VTE and 1 185 079 matched controls. This included 44 685 patients with a diagnosis of cancer at/or within 1 year before a VTE diagnosis. Female patients with VTE had a higher multivariable adjusted odds ratios of preceding cancer than male patients with VTE (5.5 [99% confidence interval 5.4-5.7] vs 3.9 [3.8-4.0]). The highest risk of cancer in patients with VTE were found for pancreatic cancer (women: 19.6 [15.8-24.4]; men: 17.2 [13.7-21.6]) and brain cancer (women: 17.4 [12.9-23.4]; men: 17.5 [13.8-22.2]). Weak associations were seen between VTE and bladder/urothelial cancer (women: 1.31 [1.12-1.53]; men: 1.34 [1.23-1.47]), prostate cancer (men: 2.17 [2.07-2.27]), malignant melanoma (women: 2.51 [2.07-3.05]; men: 2.67 [2.23-3.18]), and kidney cancer (women: 3.20 [2.49-4.11]; men: 3.33 [2.79-4.07]). In conclusion, associations with VTE were weak for bladder/urothelial cancer and kidney cancer, and strong for pancreatic, brain, and biliary cancers.
摘要：
癌症是静脉血栓栓塞（VTE）的危险因素。我们旨在通过进行一项基于瑞典注册的全国性研究来定义首次VTE患者的性别特异性癌症风险，该研究包括298172例VTE患者和1185079例匹配对照。这包括在VTE诊断前一年或一年内诊断为癌症的44685名患者。女性VTE患者的多变量校正比值比高于男性VTE患者（5.5[99％置信区间5.4-5.7]vs3.9[3.8-4.0]）。VTE患者的癌症风险最高的是胰腺癌（女性：19.6[15.8-24.4];男性：17.2[13.7-21.6]）和脑癌（女性：17.4[12.9-23.4];男性：17.5[13.8-22.2]）。VTE与膀胱/尿路上皮癌之间存在弱关联（女性：1.31[1.12-1.53]；男性：1.34[1.23-1.47]），前列腺癌（男性：2.17[2.07-2.27]），恶性黑色素瘤（女性：2.51[2.07-3.05]；男性：2.67[2.23-3.18]），和肾癌（女性：3.20[2.49-4.11]；男性：3.33[2.79-4.07]）。总之,膀胱/尿路上皮癌和肾癌与VTE的相关性较弱，胰腺强壮，大脑,和胆道癌。
