关键词: atypical dermatology leprosy unusual

Mesh : Humans Leprosy, Lepromatous / complications diagnosis pathology Leprosy / complications diagnosis Erythema Skin Diseases, Genetic Syphilis

来  源:   DOI:10.1093/trstmh/trad003

Abstract:
Conventionally, leprosy has been divided into various spectra of presentation ranging from the tuberculoid to the lepromatous pole, as well as histoid, pure neuritic leprosy and reactional states. This however is an oversimplification as leprosy can present in unusual clinical forms that may obfuscate the diagnosis. Our objective was to highlight unusual clinical presentations of leprosy occurring across all spectra of the disease. Our case series describes eight uncommon presentations of leprosy seen over a period of 10 y from 2011 to 2021, wherein clinical diagnosis followed by a histopathological confirmation of leprosy was performed. These include rare presentations such as psoriasiform plaques, Lazarine leprosy, verrucous plaques and hypertrophic scarring. Many of these rare presentations remain hitherto unreported, such as primary hypogonadism and annular plaques mimicking erythema annulare centrifugum and erythema gyratum repens. Sarcoidosis and syphilis have been labeled as great mimickers in dermatology. The current case series and review is an attempt to highlight a multitude of unusual presentations of leprosy that need a separate mention to make a correct and timely diagnosis and prevent the debilitating sequelae of this otherwise treatable infectious disease.
摘要:
传统上,麻风病已分为从结核菌到麻风病极的各种光谱,以及组织,纯神经炎麻风病和反应状态。然而,这是过度简化,因为麻风病可能以异常的临床形式出现,可能会混淆诊断。我们的目标是强调麻风病在所有疾病谱中发生的异常临床表现。我们的病例系列描述了2011年至2021年10年间发现的八种罕见的麻风病表现,其中进行了临床诊断,然后进行了麻风病的组织病理学确认。这些包括罕见的表现,如银屑病样斑块,拉扎林麻风病,疣状斑块和肥厚性瘢痕。这些罕见的演讲中的许多至今仍未报道,如原发性性腺功能减退症和环状斑块模仿环带性红斑离心和旋回性红斑。结节病和梅毒在皮肤病学中被标记为伟大的模仿者。当前的病例系列和审查是试图强调许多麻风病的不寻常表现,需要单独提及才能做出正确和及时的诊断,并防止这种本来可以治疗的传染病的衰弱后遗症。
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