PDF(Pubmed)
Abstract：
Di (2-ethyl-hexyl) phthalate (DEHP), one of endocrine-disrupting chemicals (EDCs), has widespread concern due to its serious health hazards. Exposure to DEHP in the early stage of life affects fetal metabolic and endocrine function, which even would cause genetic lesions. To date, it is widely believed that the increasing incidence of childhood obesity and diabetes in adolescents is related to the impact of DEHP on glucose and lipid homeostasis in children. However, there remains a knowledge gap to recognize these adverse effects. Thus, in this review, besides the exposure routes and levels of DEHP, we further outline the effects of early-life exposure to DEHP on children and potential mechanisms, focusing on the aspect of metabolic and endocrine homeostasis.
摘要：
邻苯二甲酸二(2-乙基己基)酯(DEHP),一种内分泌干扰化学物质（EDC），因其严重的健康危害而受到广泛关注。在生命的早期阶段暴露于DEHP会影响胎儿的代谢和内分泌功能，甚至会导致遗传损伤。迄今为止,人们普遍认为，青少年儿童肥胖和糖尿病的发病率增加与DEHP对儿童糖脂稳态的影响有关。然而,认识到这些不利影响仍然存在知识差距。因此，在这次审查中,除了DEHP的暴露途径和水平，我们进一步概述了早期接触DEHP对儿童的影响和潜在机制，专注于代谢和内分泌稳态方面。
