Abstract：
Malaria is a public health problem that causes thousands of deaths, primarily in children in African regions. Artemisinin-based combination therapies (ACTs) have helped to save thousands of lives; however, due to Plasmodium\'s resistance to available treatments, there is a need to search for new low-cost drugs that act through different mechanisms of action to contain this disease. This review shows that compounds with sulfonamide moiety, possibly, act as inhibitors of P. falciparum carbonic anhydrases, moreover, when linked to a variety of heterocycles potentiate the activities of these compounds and may be used in the design of new antimalarial drugs.
摘要：
疟疾是一个公共健康问题，导致数千人死亡，主要是非洲地区的儿童。青蒿素为基础的联合疗法（ACTs）帮助挽救了成千上万的生命；然而，由于疟原虫对现有治疗的抵抗力，有必要寻找新的低成本药物，通过不同的作用机制来控制这种疾病。这篇综述表明，具有磺酰胺基团的化合物，可能,作为恶性疟原虫碳酸酐酶的抑制剂，此外,当与各种杂环连接时，可以增强这些化合物的活性，并可用于设计新的抗疟药物。
