Abstract：
OBJECTIVE: To systematically investigate if there is a significant association between markers of autonomic functioning and emotional dysregulation (ED) in children and adolescents.
METHODS: Based on a preregistered protocol (PROSPERO: CRD42021239635), PubMed, Web of Knowledge/Science, Ovid MEDLINE, Embase, and APA PsycInfo databases were searched until April 21, 2021, to identify empirical studies reporting indices of autonomic nervous system (ANS) functioning in youths meeting DSM (version III, IV, IV-TR, 5 or 5-TR) or International Classification of Diseases (ICD) (version 9 or 10) criteria for any psychopathological/neurodevelopmental condition and assessed for ED with a validated scale. Eligible outcomes included correlation coefficients between ED and ANS measures or differences in ANS measures between youths with and without ED. Study quality was assessed with the Appraisal tool for Cross-Sectional Studies (AXIS) and the Newcastle-Ottawa Scale (NOS) for cohort studies. Random-effects meta-analyses were used for data synthesis.
RESULTS: There were 12 studies (1,016 participants) included in the descriptive review and 9 studies (567 participants) included in the meta-analyses. No evidence of a significant association between ED and altered cardiac or electrodermal functioning was found. However, exploratory meta-regressions suggested a possible association between reduced resting-state cardiac vagal control and increased ED.
CONCLUSIONS: This study did not find evidence of an association between ED and autonomic dysfunction. However, preliminary evidence that reduced vagal control at rest might be a transdiagnostic marker of ED in young people was found. Additional studies comparing autonomic measures in youths with and without ED are needed and should also assess the effects of interventions for ED on ANS functioning.
UNASSIGNED: Systematic Review and Meta-Analysis: Is Autonomic Nervous System Functioning Atypical in Children and Adolescents With Emotional Dysregulation? https://www.crd.york.ac.uk/prospero/; CRD42021239635.
METHODS: Based on a preregistered protocol (PROSPERO: CRD42021239635), PubMed, Web of Knowledge/Science, Ovid MEDLINE, Embase, and APA PsycInfo databases were searched until April 21, 2021, to identify empirical studies reporting indices of autonomic nervous system (ANS) functioning in youths meeting DSM (version III, IV, IV-TR, 5 or 5-TR) or International Classification of Diseases (ICD) (version 9 or 10) criteria for any psychopathological/neurodevelopmental condition and assessed for ED with a validated scale. Eligible outcomes included correlation coefficients between ED and ANS measures or differences in ANS measures between youths with and without ED. Study quality was assessed with the Appraisal tool for Cross-Sectional Studies (AXIS) and the Newcastle-Ottawa Scale (NOS) for cohort studies. Random-effects meta-analyses were used for data synthesis.
RESULTS: There were 12 studies (1,016 participants) included in the descriptive review and 9 studies (567 participants) included in the meta-analyses. No evidence of a significant association between ED and altered cardiac or electrodermal functioning was found. However, exploratory meta-regressions suggested a possible association between reduced resting-state cardiac vagal control and increased ED.
CONCLUSIONS: This study did not find evidence of an association between ED and autonomic dysfunction. However, preliminary evidence that reduced vagal control at rest might be a transdiagnostic marker of ED in young people was found. Additional studies comparing autonomic measures in youths with and without ED are needed and should also assess the effects of interventions for ED on ANS functioning.
UNASSIGNED: Systematic Review and Meta-Analysis: Is Autonomic Nervous System Functioning Atypical in Children and Adolescents With Emotional Dysregulation? https://www.crd.york.ac.uk/prospero/; CRD42021239635.
摘要：
目的：系统地调查儿童和青少年自主神经功能标志物与情绪失调（ED）之间是否存在显着关联。
方法：基于预先注册的协议（PROSPERO：CRD42021239635），我们搜索了Pubmed,WebofKnowledge/Science,OvidMedline,Embase和APAPsycInfo（2021年4月21日），包括实证研究，报告年轻人的自主神经系统（ANS）功能指数符合DSM/ICD标准，适用于任何精神病理学/神经发育状况，并使用经过验证的量表评估ED。合格的结果包括ED和ANS测量之间的相关系数或有和没有ED的年轻人之间的ANS测量差异。使用横断面研究评估工具（AXIS）和队列研究的纽卡斯尔-渥太华量表（NOS）评估研究质量。随机效应荟萃分析用于数据综合。
结果：12项研究（1016名参与者）纳入描述性综述，9项研究（567名参与者）纳入荟萃分析。我们没有发现ED与心脏或皮肤电功能改变之间存在显着关联的证据。然而,探索性荟萃回归提示静息状态下心脏迷走神经控制降低与ED升高之间可能存在关联.
结论：我们的研究没有发现ED与自主神经功能障碍之间存在关联的证据。然而,我们发现初步证据表明,在年轻人中,静息时迷走神经控制降低可能是ED的诊断标志.需要进一步的未来研究，比较有和没有ED的年轻人的自主神经措施，并应评估ED干预措施对ANS功能的影响。
方法：基于预先注册的协议（PROSPERO：CRD42021239635），
结果：12项研究（1016名参与者）纳入描述性综述，9项研究（567名参与者）纳入荟萃分析。
结论：我们的研究没有发现ED与自主神经功能障碍之间存在关联的证据。
