Abstract：
Amphiphilic Janus dendrimers are arrangements containing both hydrophilic and hydrophobic units, capable of forming ordered aggregates by intermolecular noncovalent interactions between the dendrimer units. Compared to conventional dendrimers, these molecular self-assemblies possess particular and effective attributes i.e., the presence of different terminal groups, essential to design new elaborated materials. The present review will focus on the pharmaceutical and biomedical application of amphiphilic Janus dendrimers. Important information for the development of novel optimized pharmaceutical formulations, such as structural classification, synthetic pathways, properties and applications, will offer the complete characterization of this type of Janus dendrimers. This work will constitute an up-to-date background for dendrimer specialists involved in designing amphiphilic Janus dendrimer-based nanomaterials for future innovations in this promising field.
摘要：
两亲性Janus树枝状聚合物是包含亲水和疏水单元的排列，能够通过树枝状聚合物单元之间的分子间非共价相互作用形成有序聚集体。与传统的树枝状聚合物相比，这些分子自组装具有特定和有效的属性，即不同终端组的存在，设计新的精心制作的材料是必不可少的。本文将重点介绍两亲性Janus树枝状聚合物的药物和生物医学应用。开发新型优化药物制剂的重要信息，如结构分类，合成途径，属性和应用，将提供这种类型的Janus树枝状聚合物的完整表征。这项工作将为参与设计基于两亲性Janus树枝状聚合物的纳米材料的树枝状聚合物专家提供最新背景，以便在这个有前途的领域进行未来的创新。
