Abstract：
The oral route is the most preferred route for systemic and local drug delivery. However, the oral drug delivery system faces the harsh physiological and physicochemical environment of the gastrointestinal tract, which limits the bioavailability and targeted design of oral drug delivery system. Innovative pharmaceutical approaches including nanoparticulate formulations, biomimetic drug formulations, and microfabricated devices have been explored to optimize drug targeting and bioavailability. In this review, the anatomical factors, biochemical factors, and physiology factors that influence delivering drug via oral route are discussed and recent advance in conventional and novel oral drug delivery approaches for improving drug bioavailability and targeting ability are highlighted. We also address the challenges and opportunities of oral drug delivery systems in future.
摘要：
口服途径是全身和局部药物递送的最优选途径。然而,口服给药系统面临着胃肠道恶劣的生理和理化环境,限制了口服给药系统的生物利用度和靶向设计。创新的药物方法，包括纳米颗粒制剂，仿生药物制剂,和微加工设备已经被探索以优化药物靶向和生物利用度。在这次审查中,解剖学因素，生化因素，讨论了影响通过口服途径递送药物的生理因素，并强调了提高药物生物利用度和靶向能力的常规和新型口服药物递送方法的最新进展。我们还应对未来口服药物递送系统的挑战和机遇。
