Abstract：
Interest in host epigenetic changes during apicomplexan infections increased in the last decade, mainly due to the emergence of new therapies directed to these alterations. This review aims to carry out a bibliometric analysis of the publications related to host epigenetic changes during apicomplexan infections and to summarize the main studied pathways in this context, pointing out those that represent putative drug targets. We used four databases for the article search. After screening, 116 studies were included. The bibliometric analysis revealed that the USA and China had the highest number of relevant publications. The evaluation of the selected studies revealed that Toxoplasma gondii was considered in most of the studies, non-coding RNA was the most frequently reported epigenetic event, and host defense was the most explored pathway. These findings were reinforced by an analysis of the co-occurrence of keywords. Even though we present putative targets for repurposing epidrugs and ncRNA-based drugs in apicomplexan infections, we understand that more detailed knowledge of the hosts\' epigenetic pathways is still needed before establishing a definitive drug target.
摘要：
在过去的十年中，人们对尖丛感染期间宿主表观遗传变化的兴趣有所增加，主要是由于针对这些改变的新疗法的出现。这篇综述的目的是进行文献计量学分析的出版物相关的宿主表观遗传变化在尖丛感染和总结的主要研究途径，在这种情况下，指出代表推定药物靶标的那些。我们使用了四个数据库进行文章搜索。筛选后,共纳入116项研究。文献计量分析显示，美国和中国的相关出版物数量最多。对选定研究的评估显示，大多数研究都考虑了弓形虫，非编码RNA是最常报道的表观遗传事件，宿主防御是探索最多的途径。通过对关键词共现的分析，这些发现得到了加强。尽管我们提出了在尖丛感染中重新利用epidrugs和基于ncRNA的药物的推定靶标，我们知道,在确定明确的药物靶点之前,还需要对宿主的表观遗传途径有更详细的了解.
