Abstract：
Erucic acid (EA) is monounsaturated fatty acid (22:1 n-9), synthesized in the seeds of many plants from the Brassicaceae family, with Brassica napus, B. rapa, or B. carinata considered as its richest source. As the compound has been blamed for the poisoning effect in Toxic Oil Syndrome, and some data indicated its cardiotoxicity to rats, EA has been for decades classified as toxic substance, the use of which should be avoided. However, the cardiac adverse effects of EA have not been confirmed in humans, and the experiments in animal models had many limitations. Thus, the aim of this review was to present the results of the so far published studies on both toxic, and pharmacological properties of EA, trying to answer the question on its future medicinal use. Despite the ambiguous and relatively small data on toxic and beneficial effects of EA it seems that the compound is worth investigating. Further research should be particularly directed at the verification EA toxicity, more in-depth studies on its neuroprotective and cytotoxic properties, but also its use in combination with other drugs, as well as its role as a drug carrier.
摘要：
芥酸（EA）是单不饱和脂肪酸（22：1n-9），在十字花科许多植物的种子中合成，与甘蓝型油菜，B.rapa,或B.carinata被认为是其最丰富的来源。由于该化合物被指责为有毒油综合症的中毒效应，一些数据表明它对大鼠的心脏毒性，几十年来，EA一直被归类为有毒物质，应避免使用。然而,EA的心脏不良反应尚未在人类中得到证实，动物模型的实验有很多局限性。因此，这篇综述的目的是介绍迄今为止发表的关于这两种有毒物质的研究的结果，和EA的药理特性，试图回答其未来药用的问题。尽管关于EA的毒性和有益作用的数据不明确且相对较小，但似乎该化合物值得研究。进一步的研究应特别针对验证EA毒性，对其神经保护和细胞毒性特性进行了更深入的研究，而且它与其他药物联合使用，以及它作为药物载体的作用。
