Abstract：
Integrative and conjugative elements (ICEs) are mobile DNA molecules that can be transferred through excision, conjugation, and integration into chromosomes. They contribute to the horizontal transfer of genomic islands across bacterial species. ICEs carrying genes encoding aromatic compound degradation pathways are of interest because of their contribution to environmental remediation. Recent advances in DNA sequencing technology have increased the number of newly discovered ICEs in bacterial genomes and have enabled comparative analysis of their evolution. The two different families of ICEs carry various aromatic compound degradation pathway genes. ICEclc and its related ICEs contain a number of members with diverse catabolic capabilities. In addition, the Tn4371 family, which includes ICEs that carry the chlorinated biphenyl catabolic pathway, has been identified. It is apparent that they underwent evolution through the acquisition, deletion, or exchange of modules to adapt to an environmental niche. ICEs have the property of both stability and mobility in the chromosome. Perspectives on the use of ICEs in environmental remediation are also discussed.
摘要：
整合和共轭元件（ICE）是可以通过切除转移的移动DNA分子，共轭，并整合到染色体中。它们有助于基因组岛跨细菌物种的水平转移。携带编码芳族化合物降解途径的基因的ICE由于其对环境修复的贡献而受到关注。DNA测序技术的最新进展增加了细菌基因组中新发现的ICE的数量，并能够对其进化进行比较分析。ICEs的两个不同家族携带各种芳族化合物降解途径基因。ICEclc及其相关的ICE包含许多具有不同分解代谢能力的成员。此外,Tn4371家族,其中包括携带氯化联苯分解代谢途径的ICE，已被确认。很明显，他们通过收购经历了进化，删除,或交换模块以适应环境生态位。ICE在染色体中具有稳定性和移动性的特性。还讨论了在环境修复中使用ICEs的观点。
