Abstract:
The age-old axiom that one is as old as his or her vessels are, calls for ongoing critical re-examination of modifiable risk factors of accelerated vascular ageing in chronic kidney diseases. Attempts to modulate vascular risk with cholesterol-lowering agents have largely failed in advanced chronic kidney disease (CKD). In addition to nitrogen waste products, many pathological biochemical processes also play a role in vascular calcification in chronic kidney damage. Magnesium, a cation vital for the body, may substantially reduce cardiovascular diseases\' risk and progression. This narrative review aimed to address the relationship between hypomagnesemia and vascular calcification, which promotes further cardiovascular complications in diabetes, aging, and CKD. Articles with predefined keywords were searched for in the PubMed and Google Scholar databases with specific inclusion and exclusion criteria. We hypothesized that a decrease in serum magnesium levels contributes to increased vascular calcification and thereby increases cardiovascular mortality. In summary, based on existing evidence in the literature, it appears that simple and inexpensive oral magnesium supplementation may reduce the cardiovascular mortality of patients who are already severely affected by such diseases; in this context, the concept of \'normal\' vs. \'ideal\' serum magnesium levels should be carefully re-examined.
摘要:
一个人和他或她的血管一样古老的公理,呼吁对慢性肾脏病加速血管老化的可改变危险因素进行持续的严格重新检查.在晚期慢性肾脏疾病(CKD)中,使用降胆固醇药物调节血管风险的尝试在很大程度上失败了。除了氮废物,许多病理生化过程也在慢性肾损害的血管钙化中发挥作用。镁,对身体至关重要的阳离子,可以大大降低心血管疾病的风险和进展。这篇叙述性综述旨在解决低镁血症与血管钙化之间的关系。这进一步促进了糖尿病的心血管并发症,老化,CKD。在PubMed和GoogleScholar数据库中搜索了具有预定义关键字的文章,这些文章具有特定的包含和排除标准。我们假设血清镁水平的降低有助于血管钙化的增加,从而增加心血管死亡率。总之,根据文献中的现有证据,看来,简单而廉价的口服镁补充剂可以降低已经严重受此类疾病影响的患者的心血管死亡率;在这种情况下,“正常”的概念与“理想的”血清镁水平应仔细重新检查。