Abstract：
Superparamagnetic iron oxide nanoparticles (SPION) are widely used in bone tissue engineering because of their unique physical and chemical properties and their excellent biocompatibility. Under the action of a magnetic field, SPIONs loaded in a biological scaffold can effectively promote osteoblast proliferation, differentiation, angiogenesis, and so on. SPIONs have very broad application prospects in bone repair, bone reconstruction, bone regeneration, and other fields. In this paper, several methods for forming biological scaffolds via the biological assembly of SPIONs are reviewed, and the specific applications of these biological scaffolds in bone tissue engineering are discussed.
摘要：
超顺磁性氧化铁纳米粒子(SPION)因其奇特的物理化学性质和优越的生物相容性而被普遍运用于骨组织工程中。在磁场的作用下，负载于生物支架中的SPIONs能有效促进成骨细胞增殖,分化,血管生成,等等。SPIONS在骨修复中具有非常广阔的应用前景,骨重建,骨再生,和其他领域。在本文中,综述了通过SPIONs生物组装形成生物支架的几种方法，并讨论了这些生物支架在骨组织工程中的具体应用。
