Abstract：
Canine vaccination is the main tool for preventing dangerous and widespread diseases. The strongly recommended (core) dog vaccines are against Canine Parvovirus type 2 (CPV-2), Canine Distemper Virus (CDV), and Canine Adenovirus (CAdV-1), but vaccination protocols should be tailored to dog lifestyles. Vaccination guidelines suggest vaccinating adult dogs no more frequently than every 3 years using modified live (attenuated) vaccines (MLV), thus obtaining a long-lasting (sometimes throughout life) specific protection in many but not all animals. The aim of this study was to determine the actual levels of seroprotection against CPV-2, CDV and CAdV-1 in a cohort of Italian dogs by using the in-practice test VacciCheck. A total of 1,027 dogs (951 vaccinated and 76 unvaccinated) were analyzed for Protective Antibody Titers (PATs) against CPV-2, CDV, and CAdV-1. Differences related to sex, age, breed size, health status, and time elapsed since last vaccination were evaluated. Half of the entire canine cohort (50.6%) had PATs for all three viruses (68.5% considering only vaccinated dogs). In particular, 90.8% of dogs were protected against CPV-2, 68.6% against CDV, and 79.8% against CAdV-1. Most dogs remained protected for 3 years after vaccination or longer. Revaccination on a 3-year basis can then be recommended for core MLV vaccines without altering individual\'s seroprotection or even herd immunity.
摘要：
犬疫苗接种是预防危险和广泛疾病的主要工具。强烈推荐的（核心）犬疫苗是针对犬细小病毒2型（CPV-2），犬瘟热病毒（CDV），和犬腺病毒（CAdV-1），但是疫苗接种协议应该适合狗的生活方式。疫苗接种指南建议使用改良的活（减毒）疫苗（MLV）接种成年犬的频率不超过每3年。从而在许多但并非所有动物中获得持久（有时贯穿一生）的特定保护。这项研究的目的是通过使用实践测试VacciCheck来确定一组意大利狗中针对CPV-2，CDV和CAdV-1的血清保护的实际水平。总共分析了1,027只狗（951只接种疫苗和76只未接种疫苗）针对CPV-2，CDV，和cadv-1。与性别有关的差异，年龄,品种大小,健康状况,和自上次疫苗接种以来经过的时间进行了评估。整个犬类队列的一半（50.6％）具有所有三种病毒的PAT（68.5％仅考虑接种疫苗的狗）。特别是,90.8%的狗受到CPV-2的保护，68.6%的狗受到CDV的保护，和79.8%对cadv-1。大多数狗在接种疫苗后3年或更长时间保持保护。然后，可以建议对核心MLV疫苗进行3年的再接种，而不会改变个体的血清保护甚至群体免疫力。
