METHODS: A retrospective observational study including patients diagnosed with Best disease.
METHODS: Fifty-nine eyes of thirty-two patients (fifteen females (46.9%) and seventeen males (53.1%), p = 0.9) diagnosed with Best disease were included. Patients\' eyes were categorized into two groups: Eyes with a fovea plana appearance (\'FP group\') and eyes without fovea plana appearance (\'no FP group\'), based on the foveal appearance on B-scan SD-OCT.
METHODS: Cross-sectional OCT images were assessed for the persistence of inner retinal layers (IRL) and OCT-A was analyzed for the presence of a foveal avascular zone (FAZ), the size of which was determined when applicable.
RESULTS: Overall, 16 eyes (27.1%) of 9 patients had a fovea plana appearance (\'FP group\') with the persistence of IRL, and 43 eyes (72.9%) of 23 patients did not have fovea plana appearance (\'no FP group\'). Among FP eyes, OCT-A performed in 13 eyes showed bridging vessels through the FAZ in 100% of eyes with OCT-A. Using Thomas classification, 14 out of the 16 eyes with fovea plana (87.5%) had atypical foveal hypoplasia, and the 2 others (12.5%) had a grade 1b fovea plana.
CONCLUSIONS: In our series, foveal hypoplasia was present in 27.1% of patients with Best disease. OCT-A showed bridging vessels through the FAZ in all eyes. These findings highlight the microvascular changes associated with Best disease, which can be an early sign of the disease in patients with a family history.
方法:一项回顾性观察研究,包括诊断为Best疾病的患者。
方法:32例患者59只眼(女性15例(46.9%),男性17例(53.1%),
方法:评估横截面OCT图像中视网膜内层(IRL)的持久性,并分析OCT-A中是否存在中央凹无血管区(FAZ),
结果:总体而言,
结论:在我们的系列中,