PDF(Pubmed)
Abstract：
Periodontal diseases are one of the main causes of tooth loss and the second most common oral disease after carries. Patients with autoimmune diseases, such as Hashimoto\'s disease, are more often vulnerable to infection. In the study group of patients, despite the lack of other signs of gingivitis, bleeding occurred after tooth brushing or minor trauma. Bleeding on probing is the first objective sign of ongoing inflammation. The study was conducted on a group of 17 patients diagnosed with Hashimoto\'s disease. The atelocollagen Linerase (100 mg) thinned with 5 mL 0.9% NaCl was used. A total of 0.05 mL of solution was injected into keratinized gingiva, two millimeters above the gingival papillae basement, four times in two-week intervals. The greatest decrease in the number of bleeding points was observed after the first and second injections of atelocollagen. After the third and fourth injections, the average BOP continued to decrease, but the decline was very slow. The use of atelocollagen made it possible to eliminate bleeding symptoms in the study group.
摘要：
牙周病是牙齿脱落的主要原因之一，也是继牙周病之后第二常见的口腔疾病。自身免疫性疾病患者，比如桥本病,更容易受到感染。在研究组患者中，尽管没有其他牙龈炎的迹象，刷牙或轻微创伤后出血。探查出血是持续炎症的第一个客观迹象。这项研究是在一组17名诊断为桥本病的患者中进行的。使用用5mL0.9%NaCl稀释的去端胶原Linerase(100mg)。将总共0.05mL的溶液注射到角化的牙龈中，牙龈乳头基底上方两毫米，两周间隔四次。第一次和第二次注射前胶原后，出血点的数量减少最大。第三次和第四次注射后，平均防喷器继续下降，但是下降非常缓慢。使用去端胶可以消除研究组的出血症状。
